Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
about
The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complexPARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformationVault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivoProtein requirements for sister telomere association in human cellsThe formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenanceStructural basis of selective ubiquitination of TRF1 by SCFFbx4POT1 association with TRF2 regulates telomere lengthDisruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human CellsHuman protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitroTankyrase 1 regulates centrosome function by controlling CPAP stabilityThe macro domain is an ADP-ribose binding moduleHuman telomerase and its regulationShelterin complex and associated factors at human telomeresFunctional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongationRDX induces aberrant expression of microRNAs in mouse brain and liverNuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant CellReaders of poly(ADP-ribose): designed to be fit for purposeTankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals.Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast.ATM Kinase Is Required for Telomere Elongation in Mouse and Human CellsLoss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer CellsTRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeresIdentification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partnerTelomere length and genetic analyses in population-based studies of endometrial cancer riskTelomerase inhibitor Imetelstat (GRN163L) limits the lifespan of human pancreatic cancer cellsGeneration and characterization of telomere length maintenance in tankyrase 2-deficient mice.Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and cappingVertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerizationNuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation.Natural and pharmacological regulation of telomeraseTankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic developmentIdentification of a novel murine pancreatic tumour antigen, which elicits antibody responses in patients with pancreatic carcinoma.Expression of mutant RPA in human cancer cells causes telomere shortening.Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage.The oligonucleotide/oligosaccharide-binding fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage responseEvolutionary history of the poly(ADP-ribose) polymerase gene family in eukaryotes.Family-wide analysis of poly(ADP-ribose) polymerase activity
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P2860
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
description
2002 nî lūn-bûn
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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2002 թվականի հունվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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name
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@ast
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@en
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@en-gb
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@nl
type
label
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@ast
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@en
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@en-gb
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@nl
prefLabel
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@ast
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@en
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@en-gb
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@nl
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Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
@en
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Brandoch D Cook
Grigoriy Shostak
Jasmin N Dynek
Susan Smith
William Chang
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P356
10.1128/MCB.22.1.332-342.2002
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2002-01-01T00:00:00Z