LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
about
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Dopamine release in the basal gangliaLeucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domainA Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityBiochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersLRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complexSynaptic vesicle trafficking and Parkinson's diseaseLRRK2 transport is regulated by its novel interacting partner Rab32Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyGTP binding controls complex formation by the human ROCO protein MASL1RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease riskLRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarizationMutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neuronsThe associations between Parkinson's disease and cancer: the plot thickensHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsThe role of the LRRK2 gene in ParkinsonismSynaptic dysfunction and septin protein family members in neurodegenerative diseasesHigh LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brainProgressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceParkinson's disease and immune system: is the culprit LRRKing in the periphery?Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to studentsLeucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brainFunctional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson's Disease: Drug Effects of Withania somnifera (Dunal) AdministrationLRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesiasProtective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degenerationMicrotubule destabilization is shared by genetic and idiopathic Parkinson's disease patient fibroblasts.Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.Upregulation of Parkin in endophilin mutant mice.Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioningThe Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus.Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2
P2860
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P248
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P2860
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@ast
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@en
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@en-gb
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@nl
type
label
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@ast
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@en
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@en-gb
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@nl
prefLabel
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@ast
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@en
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@en-gb
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@nl
P2093
P50
P3181
P1476
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
@en
P2093
Andrea Meixner
Daniela M Vogt-Weisenhorn
Hakan Sarioglu
Karsten Boldt
Marius Ueffing
Silvia De Astis
Wolfgang Wurst
P304
P3181
P356
10.1523/JNEUROSCI.3730-10.2011
P407
P50
P577
2011-02-01T00:00:00Z