Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers
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LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complexDifferential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathwaysPhosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylationGTP binding controls complex formation by the human ROCO protein MASL1Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson diseaseHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsRevisiting the Roco G-protein cycleStructural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contactsLeucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brainThe LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistributionLRRK2 autophosphorylation enhances its GTPase activityStructure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson's disease.The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate.LRRK2: cause, risk, and mechanism.Rare variants in LRRK1 and Parkinson's disease.Role and mechanism of action of leucine-rich repeat kinase 1 in bone.Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).Leucine-rich repeat kinase 2 inhibitors: a review of recent patents (2011 - 2013).Genetic, structural, and molecular insights into the function of ras of complex proteins domains.LRRK2 pathobiology in Parkinson's disease.Cellular processes associated with LRRK2 function and dysfunctionLRRK2 Pathways Leading to Neurodegeneration.Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1.Parkinson disease-associated LRRK2 G2019S transgene disrupts marrow myelopoiesis and peripheral Th17 response.In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.LRRK2 dephosphorylation increases its ubiquitination.LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.Synthesis and In Vitro and In Vivo Evaluation of [3H]LRRK2-IN-1 as a Novel Radioligand for LRRK2.A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.Regulation of LRRK2 by Phosphatases.Molecular Insights and Functional Implication of LRRK2 Dimerization.Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.
P2860
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P2860
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Biochemical characterization o ...... trates formation of homodimers
@ast
Biochemical characterization o ...... trates formation of homodimers
@en
Biochemical characterization o ...... trates formation of homodimers
@en-gb
Biochemical characterization o ...... trates formation of homodimers
@nl
type
label
Biochemical characterization o ...... trates formation of homodimers
@ast
Biochemical characterization o ...... trates formation of homodimers
@en
Biochemical characterization o ...... trates formation of homodimers
@en-gb
Biochemical characterization o ...... trates formation of homodimers
@nl
prefLabel
Biochemical characterization o ...... trates formation of homodimers
@ast
Biochemical characterization o ...... trates formation of homodimers
@en
Biochemical characterization o ...... trates formation of homodimers
@en-gb
Biochemical characterization o ...... trates formation of homodimers
@nl
P2093
P2860
P50
P921
P1433
P1476
Biochemical characterization o ...... trates formation of homodimers
@en
P2093
Fangye Gao
Laura Civiero
Lauran Reyniers
Renée Vancraenenbroeck
P2860
P304
P356
10.1371/JOURNAL.PONE.0043472
P407
P50
P577
2012-01-01T00:00:00Z