E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression
about
The transcription factor p53: not a repressor, solely an activatorThe C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivoIdentification of a Low-Frequency Missense Variant in E2F Transcription Factor 7 Associated with Colorectal Cancer Risk In A Chinese PopulationE2F8 is a Potential Therapeutic Target for Hepatocellular CarcinomaCtBP2 proteome: Role of CtBP in E2F7-mediated repression and cell proliferationThe DREAM complex: master coordinator of cell cycle-dependent gene expression.Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution abilityTranscriptome-wide signatures of tumor stage in kidney renal clear cell carcinoma: connecting copy number variation, methylation and transcription factor activity.Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements.Expression of p53 target genes in the early phase of long-term potentiation in the rat hippocampal CA1 areap53 loss increases the osteogenic differentiation of bone marrow stromal cellsFeedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing.Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.Rap2b, a novel p53 target, regulates p53-mediated pro-survival functionInteraction of E2F7 transcription factor with E2F1 and C-terminal-binding protein (CtBP) provides a mechanism for E2F7-dependent transcription repressionCell cycle regulation by checkpoints.Identification of cellular senescence-specific genes by comparative transcriptomics.Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer.Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo.Antitumor mechanisms when pRb and p53 are genetically inactivated.Identifying Novel Transcriptional Regulators with Circadian Expression.E2F Transcription Factors Control the Roller Coaster Ride of Cell Cycle Gene Expression.Census and evaluation of p53 target genes.Parallel profiling of the transcriptome, cistrome, and epigenome in the cellular response to ionizing radiation.Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage.Large-scale RNA-Seq Transcriptome Analysis of 4043 Cancers and 548 Normal Tissue Controls across 12 TCGA Cancer Types.Identification of a p53-repressed gene module in breast cancer cells.Predicting essential genes and synthetic lethality via influence propagation in signaling pathways of cancer cell fates.A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer.Characterization of the 5'-flanking region of the human TP53 gene and its response to the natural compound, Resveratrol.Genome-wide functional analysis on the molecular mechanism of specifically biosynthesized fluorescence Eu complex.An Atypical Oncogene Within the Atypical E2Fs.TP53 Regulates Transcription of Cell Cycle GenesTP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestPharmacological inhibition of the transcription factor PU.1 in leukemia.A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression.Mechanisms of transcriptional regulation by p53.
P2860
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P2860
E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
E2F7, a novel target, is up-re ...... ent transcriptional repression
@ast
E2F7, a novel target, is up-re ...... ent transcriptional repression
@en
E2F7, a novel target, is up-re ...... ent transcriptional repression
@en-gb
E2F7, a novel target, is up-re ...... ent transcriptional repression
@nl
type
label
E2F7, a novel target, is up-re ...... ent transcriptional repression
@ast
E2F7, a novel target, is up-re ...... ent transcriptional repression
@en
E2F7, a novel target, is up-re ...... ent transcriptional repression
@en-gb
E2F7, a novel target, is up-re ...... ent transcriptional repression
@nl
prefLabel
E2F7, a novel target, is up-re ...... ent transcriptional repression
@ast
E2F7, a novel target, is up-re ...... ent transcriptional repression
@en
E2F7, a novel target, is up-re ...... ent transcriptional repression
@en-gb
E2F7, a novel target, is up-re ...... ent transcriptional repression
@nl
P2860
P921
P3181
P356
P1433
P1476
E2F7, a novel target, is up-re ...... ent transcriptional repression
@en
P2093
James J Manfredi
Luis A Carvajal
P2860
P304
P3181
P356
10.1101/GAD.184911.111
P407
P577
2012-07-01T00:00:00Z