MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2 - Wikidata - wikimedia - TriplyDB

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

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A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans The biomarkers of immune dysregulation and inflammation response in Parkinson disease Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor design Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.Efficient allele-specific targeting of LRRK2 R1441 mutations mediated by RNAi.Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution Role of LRRK2 kinase dysfunction in Parkinson disease Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia.Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.Models for LRRK2-Linked Parkinsonism.Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease.LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.Pathway for Parkinson disease.Understanding the molecular basis of Parkinson's disease, identification of biomarkers and routes to therapy.Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies.Mechanisms of LRRK2-mediated neurodegeneration.Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease.Phosphorylation of LRRK2: from kinase to substrate.Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease.Kinase inhibitors for CNS diseases: an analysis of the recent patent literature.New insight into neurodegeneration: the role of proteomics.Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis Interaction of LRRK2 with kinase and GTPase signaling cascades

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P2860

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

http://www.wikidata.org/entity/Q24294736

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@ast

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@en

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@en-gb

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@nl

type

label

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@ast

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@en

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@en-gb

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@nl

prefLabel

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@ast

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@en

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@en-gb

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@nl

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J.1471-4159.2010.06568.X

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Journal of Neurochemistry

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MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

@en

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Andrew Ferree

http://www.w3.org/2001/XMLSchema#string

Benjamin Wolozin

http://www.w3.org/2001/XMLSchema#string

Cindy H Hsu

http://www.w3.org/2001/XMLSchema#string

Diane Chan

http://www.w3.org/2001/XMLSchema#string

Grace C Shen

http://www.w3.org/2001/XMLSchema#string

Kesav Raghavan

http://www.w3.org/2001/XMLSchema#string

Lilach Segal

http://www.w3.org/2001/XMLSchema#string

Maria D Guillily

http://www.w3.org/2001/XMLSchema#string

Shamol Saha

http://www.w3.org/2001/XMLSchema#string

P2860

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.

LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins

Identification of potential protein interactors of Lrrk2

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

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1593-604

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scholarly article

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2437168

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10.1111/J.1471-4159.2010.06568.X

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6

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2010-03-01T00:00:00Z

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41000256

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20067578

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Parkinson's disease

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2856721

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