CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia
about
Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in BangladeshCNNM2 mutations cause impaired brain development and seizures in patients with hypomagnesemiaBasolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse modelThe Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling PathwayMg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporterStructural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3.Genetic causes of hypomagnesemia, a clinical overviewHypomagnesemia: a clinical perspective.Inactivation of TRPM7 kinase activity does not impair its channel function in mice.Rare inherited kidney diseases: challenges, opportunities, and perspectives.Identification and lateral membrane localization of cyclin M3, likely to be involved in renal Mg2+ handling in seawater fishRenal control of calcium, phosphate, and magnesium homeostasisEfficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT.Distal convoluted tubule'Lemonade Legs': Why do Some Patients Get Profound Hypomagnesaemia on Proton-Pump Inhibitors?Sex differences in proximal and distal nephron function contribute to the mechanism of idiopathic hypercalcuria in calcium stone formers.Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles.Inhibition of PRL-2·CNNM3 Protein Complex Formation Decreases Breast Cancer Proliferation and Tumor Growth.Identification and proximal tubular localization of the Mg²⁺ transporter, Slc41a1, in a seawater fish.The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophreniaAn Essential Factor for High Mg2+ Tolerance of Staphylococcus aureus.New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemiaVascular transcriptome profiling identifies Sphingosine kinase 1 as a modulator of angiotensin II-induced vascular dysfunction.Drug-induced alterations in Mg2+ homoeostasis.The long-term complications of the inherited tubulopathies: an adult perspective.Inherited disorders of renal hypomagnesaemia.Human CNNM2 is not a Mg(2+) transporter per se.Inherited and acquired disorders of magnesium homeostasis.Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cellsPurification, crystallization and preliminary crystallographic analysis of the CBS-domain pair of cyclin M2 (CNNM2).Membrane topology and intracellular processing of cyclin M2 (CNNM2).Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis.Magnesium homeostasis in cattle: absorption and excretion.Genetics of Magnesium Disorders.Rebuttal from Francisco J. Arjona and Jeroen H. F. de Baaij.CrossTalk opposing view: CNNM proteins are not Na+ /Mg2+ exchangers but Mg2+ transport regulators playing a central role in transepithelial Mg2+ (re)absorption.CrossTalk proposal: CNNM proteins are Na+ /Mg2+ exchangers playing a central role in transepithelial Mg2+ (re)absorption.
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P2860
CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia
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2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
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CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
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CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
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CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
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CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
@ast
CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
@en
CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
@en-gb
CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
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CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
@ast
CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
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CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
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CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
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CNNM2, encoding a basolateral ...... ted in dominant hypomagnesemia
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Carsten A Wagner
Constanze Will
Dominik Müller
Huguette Debaix
Iwan C Meij
Joost G Hoenderop
Julia Thumfart
Kathrin Kopplin
Kerstin Sommer
Marchel Stuiver
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P304
P3181
P356
10.1016/J.AJHG.2011.02.005
10.5167/UZH-47687
P407
P577
2011-03-11T00:00:00Z