Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling - Wikidata - wikimedia - TriplyDB

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling Structural basis of selective ubiquitination of TRF1 by SCFFbx4 A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803 Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination Prolyl 4-hydroxylase Diversity of degradation signals in the ubiquitin-proteasome system Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1 pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2 A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation Sequence and structural analysis of BTB domain proteins Ascorbate depletion: a critical step in nickel carcinogenesis?The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions Targeting Protein-Protein Interactions in the HIF System Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor The Structure of YqeH: AN AtNOS1/AtNOA1 ORTHOLOG THAT COUPLES GTP HYDROLYSIS TO MOLECULAR RECOGNITION Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase PHD2: from hypoxia regulation to disease progression The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium The SCF ubiquitin ligase: insights into a molecular machine Solution structure of the human ubiquitin-specific protease 15 DUSP domain Substrate-mediated regulation of cullin neddylation Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme Comprehensive assessment of cancer missense mutation clustering in protein structures Capturing cooperative interactions with the PSI-MI format

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P2860

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

http://www.wikidata.org/entity/Q24297062

description

2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2002 թվականի հունիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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name

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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type

label

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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prefLabel

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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Frank Gertler

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Haifeng Yang

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Jung-Hyun Min

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Mircea Ivan

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Nikola P Pavletich

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10.1126/SCIENCE.1073440

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William G. Kaelin

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2002-06-07T00:00:00Z

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12004076

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