A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase - Wikidata - wikimedia - TriplyDB

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

http://www.wikidata.org/entity/Q27713259

about

Selective degradation of splicing factor CAPERα by anticancer sulfonamides.p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates.Induced protein degradation: an emerging drug discovery paradigm.Structural basis of PROTAC cooperative recognition for selective protein degradation Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway Drugging the 'undruggable' cancer targets.Evaluation of US 2016/0115161 A1: isoindoline compounds and methods of their use.Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth.Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma.pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.Ubiquitylation at the crossroads of development and disease.Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation.Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.Stabilization of protein-protein interactions in drug discovery.Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.Patent Highlights June-July 2017.Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome UBE2G1 governs the destruction of cereblon neomorphic substrates

P2860

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P2860

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

http://www.wikidata.org/entity/Q27713259

description

2016 nî lūn-bûn

@nan

2016 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2016 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2016年の論文

@ja

2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

name

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

@ast

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

@en

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

@nl

type

label

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

@ast

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

@en

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

@nl

prefLabel

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

@ast

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

@en

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

@nl

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P1476

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

@en

P2093

Alexander L Ruchelman

http://www.w3.org/2001/XMLSchema#string

Antonia Lopez-Girona

http://www.w3.org/2001/XMLSchema#string

Barbra Pagarigan

http://www.w3.org/2001/XMLSchema#string

Brian E Cathers

http://www.w3.org/2001/XMLSchema#string

Chin-Chun Lu

http://www.w3.org/2001/XMLSchema#string

Derek Nguyen

http://www.w3.org/2001/XMLSchema#string

Gang Lu

http://www.w3.org/2001/XMLSchema#string

Gilles Carmel

http://www.w3.org/2001/XMLSchema#string

Hiroshi Handa

http://www.w3.org/2001/XMLSchema#string

Jack Houston

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

The role of Ikaros in human erythroid differentiation

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Identification of a primary target of thalidomide teratogenicity

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway

Mechanism of auxin perception by the TIR1 ubiquitin ligase

P2888

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252-257

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scholarly article

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10.1038/NATURE18611

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P433

7611

http://www.w3.org/2001/XMLSchema#string

P478

535

http://www.w3.org/2001/XMLSchema#string

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Gabriel C. Lander

P577

2016-06-22T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

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1032903135

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27338790

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