The distinct functional properties of the nucleotide-binding domain of ATP7B, the human copper-transporting ATPase: analysis of the Wilson disease mutations E1064A, H1069Q, R1151H, and C1104F
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Solution structure of the N-domain of Wilson disease protein: distinct nucleotide-binding environment and effects of disease mutationsMolecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypesStructure of a Copper Pump Suggests a Regulatory Role for Its Metal-Binding DomainNucleotide recognition by CopA, a Cu+-transporting P-type ATPaseThe Binding Mode of ATP Revealed by the Solution Structure of the N-domain of Human ATP7AThe Architecture of CopA from Archeaoglobus fulgidus Studied by Cryo-Electron Microscopy and Computational DockingCopper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxificationConsequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout miceElucidation of the ATP7B N-domain Mg2+-ATP coordination site and its allosteric regulationThe soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin.Interactions between metal-binding domains modulate intracellular targeting of Cu(I)-ATPase ATP7B, as revealed by nanobody binding.Difference in stability of the N-domain underlies distinct intracellular properties of the E1064A and H1069Q mutants of copper-transporting ATPase ATP7B.Prevalence of ATP7B Gene Mutations in Iranian Patients With Wilson Disease.Structural Insights into the Nucleotide-Binding Domains of the P1B-type ATPases HMA6 and HMA8 from Arabidopsis thaliana.Linkage disequilibrium and haplotype analysis of the ATP7B gene in Alzheimer's disease.Identification of the heparin-binding domains of the interferon-induced protein kinase, PKRDistinct phenotype of a Wilson disease mutation reveals a novel trafficking determinant in the copper transporter ATP7B.Reduced expression of ATP7B affected by Wilson disease-causing mutations is rescued by pharmacological folding chaperones 4-phenylbutyrate and curcumin.Molecular modelling of the nucleotide-binding domain of Wilson's disease protein: location of the ATP-binding site, domain dynamics and potential effects of the major disease mutations.Crystallization and preliminary X-ray studies of the N-domain of the Wilson disease associated protein.Assessment of a putative proton relay in Arabidopsis cinnamyl alcohol dehydrogenase catalysis.Mapping the ATP binding site in the plasma membrane H(+)-ATPase from Kluyveromyces lactis.Sequence variation in the ATP-binding domain of the Wilson disease transporter, ATP7B, affects copper transport in a yeast model system.Spo0B of Bacillus anthracis - a protein with pleiotropic functions.A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism.
P2860
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P2860
The distinct functional properties of the nucleotide-binding domain of ATP7B, the human copper-transporting ATPase: analysis of the Wilson disease mutations E1064A, H1069Q, R1151H, and C1104F
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2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@ast
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@en
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@en-gb
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@nl
type
label
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@ast
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@en
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@en-gb
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@nl
prefLabel
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@ast
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@en
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@en-gb
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@nl
P2093
P2860
P3181
P356
P1476
The distinct functional proper ...... 4A, H1069Q, R1151H, and C1104F
@en
P2093
Clinton T Morgan
Roman G Efremov
Ruslan Tsivkovskii
Svetlana Lutsenko
Yuri A Kosinsky
P2860
P304
P3181
P356
10.1074/JBC.M404553200
P407
P577
2004-08-27T00:00:00Z