sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin
about
Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's DiseaseMechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrierDivalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathologyEnduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by TauThe relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin.Iron and restless legs syndrome: treatment, genetics and pathophysiology.A proposed role for efflux transporters in the pathogenesis of hydrocephalusActivation of C6 glioblastoma cell ceruloplasmin expression by neighboring human brain endothelia-derived interleukins in an in vitro blood-brain barrier model system.β-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin.Iron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy.Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease.Neonatal Iron Supplementation Induces Striatal Atrophy in Female YAC128 Huntington's Disease Mice.Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer's Disease.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Biometals and their therapeutic implications in Alzheimer's disease.Lithium suppression of tau induces brain iron accumulation and neurodegeneration.Iron dysregulates APP processing accompanying with sAPPα cellular retention and β-secretase inhibition in rat cortical neurons.Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics.MiR-144-3p and Its Target Gene β-Amyloid Precursor Protein Regulate 1-Methyl-4-Phenyl-1,2-3,6-Tetrahydropyridine-Induced Mitochondrial Dysfunction.miR-20a regulates expression of the iron exporter ferroportin in lung cancer.Bioavailable Trace Metals in Neurological Diseases.A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity.Expression of Iron-Related Proteins at the Neurovascular Unit Supports Reduction and Reoxidation of Iron for Transport Through the Blood-Brain Barrier.Can brain impermeable BACE1 inhibitors serve as anti-CAA medicine?Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease.The Ferroxidase Hephaestin But Not Amyloid Precursor Protein is Required for Ferroportin-Supported Iron Efflux in Primary Hippocampal Neurons.Tau-mediated iron export prevents ferroptotic damage after ischemic stroke.Amyloid Precursor Protein Haploinsufficiency Preferentially Mediates Brain Iron Accumulation in Mice Transgenic for The Huntington's Disease Mutation.Na+/H+ Exchanger 9 Regulates Iron Mobilization at the Blood-Brain Barrier in Response to Iron Starvation.Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress
P2860
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P2860
sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin
description
2014 nî lūn-bûn
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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@ast
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@en
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@en-gb
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@nl
type
label
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@ast
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@en
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@en-gb
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@nl
prefLabel
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@ast
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@en
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@en-gb
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@nl
P2093
P2860
P3181
P356
P1433
P1476
sAPP modulates iron efflux fro ...... rous iron exporter ferroportin
@en
P2093
Daniel J Kosman
Ryan C McCarthy
Yun-Hee Park
P2860
P304
P3181
P356
10.15252/EMBR.201338064
P407
P577
2014-07-01T00:00:00Z