Biometals and their therapeutic implications in Alzheimer's disease.
about
Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by TauStructure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer's disease.Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization.Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease.Regulation of extracellular Zn(2+) homeostasis in the hippocampus as a therapeutic target for Alzheimer's disease.Lithium suppression of tau induces brain iron accumulation and neurodegeneration.Targeting mitochondrial metal dyshomeostasis for the treatment of neurodegeneration.Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics.The Emerging Therapeutic Role of NGF in Alzheimer's Disease.Amyloid β attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca2+ , ERK1/2 and Clusterin signaling in neurons.Treatment strategies in Alzheimer's disease: a review with focus on selenium supplementation.The Complex Role of Apolipoprotein E in Alzheimer's Disease: an Overview and Update.Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases.Trehalose improves traumatic brain injury-induced cognitive impairment.Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease.Identification of key structural features of the elusive Cu-Aβ complex that generates ROS in Alzheimer's disease.Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease.Copper and Alzheimer's Disease.A Trishistidine Pseudopeptide with Ability to Remove Both CuΙ and CuΙΙ from the Amyloid-β Peptide and to Stop the Associated ROS Formation.Metallo-pathways to Alzheimer's disease: lessons from genetic disorders of copper trafficking.Copper comes of age in Melbourne.Metals and Alzheimer's Disease: How Far Have We Come in the Clinic?Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects.Polyglycerol-Based Copper Chelators for the Transport and Release of Copper Ions in Biological Environments.Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer's disease.The Amyloid-β Peptide in Amyloid Formation Processes: Interactions with Blood Proteins and Naturally Occurring Metal Ions
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P2860
Biometals and their therapeutic implications in Alzheimer's disease.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
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2015年學術文章
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name
Biometals and their therapeutic implications in Alzheimer's disease.
@en
type
label
Biometals and their therapeutic implications in Alzheimer's disease.
@en
prefLabel
Biometals and their therapeutic implications in Alzheimer's disease.
@en
P2860
P1433
P1476
Biometals and their therapeutic implications in Alzheimer's disease
@en
P2093
P2860
P2888
P304
P356
10.1007/S13311-014-0312-Z
P577
2015-01-01T00:00:00Z