7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity
about
Multiple Nudix family proteins possess mRNA decapping activityLoss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defectsApplications of Phosphate Modification and Labeling to Study (m)RNA Caps.Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes.Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS.A fluorescent HTS assay for phosphohydrolases based on nucleoside 5'-fluorophosphates: its application in screening for inhibitors of mRNA decapping scavenger and PDE-I.Identification of Drosophila and human 7-methyl GMP-specific nucleotidases.Synthesis and evaluation of fluorescent cap analogues for mRNA labelling.Potential therapeutic applications of RNA cap analogs.An excess of catalytically required motions inhibits the scavenger decapping enzyme.mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translationAnalysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding.
P2860
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P248
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P2860
7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
7-methylguanosine diphosphate ...... tently inhibits their activity
@ast
7-methylguanosine diphosphate ...... tently inhibits their activity
@en
7-methylguanosine diphosphate ...... tently inhibits their activity
@en-gb
7-methylguanosine diphosphate ...... tently inhibits their activity
@nl
type
label
7-methylguanosine diphosphate ...... tently inhibits their activity
@ast
7-methylguanosine diphosphate ...... tently inhibits their activity
@en
7-methylguanosine diphosphate ...... tently inhibits their activity
@en-gb
7-methylguanosine diphosphate ...... tently inhibits their activity
@nl
prefLabel
7-methylguanosine diphosphate ...... tently inhibits their activity
@ast
7-methylguanosine diphosphate ...... tently inhibits their activity
@en
7-methylguanosine diphosphate ...... tently inhibits their activity
@en-gb
7-methylguanosine diphosphate ...... tently inhibits their activity
@nl
P2093
P2860
P921
P356
P1433
P1476
7-methylguanosine diphosphate ...... tently inhibits their activity
@en
P2093
Anna Wypijewska
Elzbieta Bojarska
Janusz Stepinski
Maciej Lukaszewicz
Richard E Davis
P2860
P304
P356
10.1021/BI300781G
P407
P577
2012-10-09T00:00:00Z