The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases
about
A protein interaction framework for human mRNA degradation7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activityNematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpSMultiple mRNA decapping enzymes in mammalian cellsAprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activitiesCoordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopmentDcpS as a therapeutic target for spinal muscular atrophy.DcpS scavenger decapping enzyme can modulate pre-mRNA splicingMechanistic and kinetic analysis of the DcpS scavenger decapping enzymeThe hDcp2 protein is a mammalian mRNA decapping enzymeFunctional characterization of the mammalian mRNA decapping enzyme hDcp2Functional analysis of mRNA scavenger decapping enzymes.The 'scavenger' m7GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeastCytoplasmic foci are sites of mRNA decay in human cellsDcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathwayFeminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimerIn silico and in vivo analysis reveal a novel gene in Saccharomyces cerevisiae trehalose metabolismNew insights into decapping enzymes and selective mRNA decayMolecular Mechanisms of Neurodegeneration in Spinal Muscular AtrophyRecombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyondProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsCrystal structure of Dcp1p and its functional implications in mRNA decappingHigh-resolution X-ray structure of the rabbit histidine triad nucleotide-binding protein 1 (rHINT1)-adenosine complex at 1.10 Å resolutionStructural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamilyActive Site Conformational Dynamics Are Coupled to Catalysis in the mRNA Decapping Enzyme Dcp2The C-Terminal Domain from S. cerevisiae Pat1 Displays Two Conserved Regions Involved in Decapping Factor RecruitmentMultiple Nudix family proteins possess mRNA decapping activityScavenger decapping activity facilitates 5' to 3' mRNA decayIdentification of a quality-control mechanism for mRNA 5'-end capping.Subunit architecture of multimeric complexes isolated directly from cells.Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast.Messenger RNA turnover in eukaryotes: pathways and enzymesThe DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models.Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defectsApplications of Phosphate Modification and Labeling to Study (m)RNA Caps.Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies.Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications.
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P2860
The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases
description
2002 nî lūn-bûn
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2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@ast
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@en
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@en-gb
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@nl
type
label
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@ast
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@en
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@en-gb
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@nl
prefLabel
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@ast
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@en
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@en-gb
The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@nl
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P2860
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The scavenger mRNA decapping e ...... HIT family of pyrophosphatases
@en
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Megerditch Kiledjian
Nancy D Rodgers
Xinfu Jiao
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P304
P3181
P356
10.1093/EMBOJ/CDF448
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2002-09-01T00:00:00Z