VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity
about
VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligasesVprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.Noncore RAG1 regions promote Vβ rearrangements and αβ T cell development by overcoming inherent inefficiency of Vβ recombination signal sequences.Ubiquitination events that regulate recombination of immunoglobulin Loci gene segments.Molecular insights into NF2/Merlin tumor suppressor function.Histone methylation and V(D)J recombination.Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures.New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination.Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation.Discovery and validation of gene-linked diagnostic SNP markers for assessing hybridization between Largemouth bass (Micropterus salmoides) and Florida bass (M. floridanus).
P2860
Q34986007-E84EDAA5-266A-4F27-A861-B92F16B5DF75Q35931436-4B0A21D3-C31E-4011-8892-4BFA0DB76EAEQ37627838-1C1DBB81-0CCA-4148-B242-EB54B7DC5869Q38198020-0E6CB183-BF55-43A2-8BD5-7C9A95CD8988Q38204110-61C28ACB-DE83-4AFE-ACBF-BD80A2B00FFAQ38233790-B439B8B3-E917-4BA9-8F83-20ADD5F93763Q39003195-A4DAC1B3-CFEF-46D2-9BE4-0DC6654C8048Q39038472-E4399ECE-C572-4376-94B8-628D104EA15FQ39282242-16ED2B31-6941-47F9-AF2B-E5F155C9E55DQ41848109-9FD7A8B6-9EBE-4642-BDD5-D30D9193894FQ46863583-A40E565C-B3E6-4DD9-89CE-8588BAE63E63
P2860
VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@ast
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@en
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@en-gb
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@nl
type
label
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@ast
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@en
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@en-gb
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@nl
prefLabel
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@ast
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@en
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@en-gb
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@nl
P2093
P2860
P356
P1433
P1476
VprBP binds full-length RAG1 a ...... d V(D)J recombination fidelity
@en
P2093
Dirk K Anderson
Greg A Perry
Koushik Mondal
Michele D Kassmeier
Patrick C Swanson
Pawel Ciborowski
Prafulla Raval
Sarah Jackson
Sushil Kumar
Victoria L Palmer
P2860
P304
P356
10.1038/EMBOJ.2011.455
P407
P577
2012-02-15T00:00:00Z