The RAG proteins and V(D)J recombination: complexes, ends, and transposition
about
V(D)J recombination and the evolution of the adaptive immune systemVprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelityThe human THAP9 gene encodes an active P-element DNA transposaseNonhomologous end joining and V(D)J recombination require an additional factorPartial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in ArtemisFunctional and biochemical dissection of the structure-specific nuclease ARTEMISDNA double-strand breaks activate a multi-functional genetic program in developing lymphocytesExtent to which hairpin opening by the Artemis:DNA-PKcs complex can contribute to junctional diversity in V(D)J recombinationIdentification and utilization of arbitrary correlations in models of recombination signal sequencesA functional analysis of the spacer of V(D)J recombination signal sequencesFrom lymphocytes to sharks: V(D)J recombinase moves to the germlineStructural insights on the role of antibodies in HIV-1 vaccine and therapyStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisReshaping Antibody DiversityThe DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis.DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs.Snaps and mends: DNA breaks and chromosomal translocationsResponse to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AXAnalysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpointsThe response to and repair of RAG-mediated DNA double-strand breaksComputational tools for understanding sequence variability in recombination signalsPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Molluscan mobile elements similar to the vertebrate Recombination-Activating GenesDeterminants for hairpin formation in Tn10 transposition.YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locusA WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactionsGenomic DNA transposition induced by human PGBD5Impaired social recognition memory in recombination activating gene 1-deficient mice.Out-of-frame T cell receptor beta transcripts are eliminated by multiple pathways in vivoSelf-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.Thermal dependency of RAG1 self-association properties.HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent.HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex.Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells.Self-organized criticality theory of autoimmunityMechanisms of chromosomal rearrangement in the human genomeEarly embryonic chromosome instability results in stable mosaic pattern in human tissuesHistone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombinationThe origins of the Rag genes--from transposition to V(D)J recombination.Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.
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P2860
The RAG proteins and V(D)J recombination: complexes, ends, and transposition
description
2000 nî lūn-bûn
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2000 թուականին հրատարակուած գիտական յօդուած
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2000 թվականին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
The RAG proteins and V(D)J recombination: complexes, ends, and transposition
@ast
The RAG proteins and V(D)J recombination: complexes, ends, and transposition
@en
The RAG proteins and V(D)J recombination: complexes, ends, and transposition
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type
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The RAG proteins and V(D)J recombination: complexes, ends, and transposition
@ast
The RAG proteins and V(D)J recombination: complexes, ends, and transposition
@en
The RAG proteins and V(D)J recombination: complexes, ends, and transposition
@nl
prefLabel
The RAG proteins and V(D)J recombination: complexes, ends, and transposition
@ast
The RAG proteins and V(D)J recombination: complexes, ends, and transposition
@en
The RAG proteins and V(D)J recombination: complexes, ends, and transposition
@nl
P2093
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P1476
The RAG proteins and V(D)J recombination: complexes, ends, and transposition
@en
P2093
D G Schatz
I J Villey
P E Shockett
S D Fugmann
P304
P3181
P356
10.1146/ANNUREV.IMMUNOL.18.1.495
P407
P577
2000-01-01T00:00:00Z