Alpha-actinin associates with polycystin-2 and regulates its channel activity
about
Direct binding of alpha-actinin enhances TRPP3 channel activityThe human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-terminiLRRC50, a conserved ciliary protein implicated in polycystic kidney diseasePolycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alphaCell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interactionRole of PKD2 in rheotaxis in DictyosteliumPolycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cystsTRP channelsA pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7Structural interaction and functional regulation of polycystin-2 by filaminKinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.Cilium, centrosome and cell cycle regulation in polycystic kidney disease.Filamin-a increases the stability and plasma membrane expression of polycystin-2.Polycystin-2 (TRPP2) Regulation by Ca(2+) Is Effected and Diversified by Actin-Binding ProteinsDiagnosis, pathogenesis, and treatment prospects in cystic kidney disease.Filamin interacts with epithelial sodium channel and inhibits its channel function.TRPpathies.Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2.Characterization of PKD protein-positive exosome-like vesicles.Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.Function and regulation of TRPP2 at the plasma membrane.Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2.Are biological sensors modulated by their structural scaffolds? The role of the structural muscle proteins alpha-actinin-2 and alpha-actinin-3 as modulators of biological sensors.Polycystins and cellular Ca2+ signaling.Polycystins and partners: proposed role in mechanosensitivity.Activation of TRPP2 through mDia1-dependent voltage gating.Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro.Whole exome sequencing as a diagnostic tool for patients with ciliopathy-like phenotypesPolycystin and calcium signaling in cell death and survival.The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells.More than colocalizing with polycystin-1, polycystin-L is in the centrosome.Far Upstream Element-Binding Protein 1 Binds the 3' Untranslated Region of PKD2 and Suppresses Its TranslationPolycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathwayReceptor for activated C kinase 1 (RACK1) inhibits function of transient receptor potential (TRP)-type channel Pkd2L1 through physical interaction.Calcium transport and local pool regulate polycystin-2 (TRPP2) function in human syncytiotrophoblast.Autosomal Dominant Polycystic Kidney Patients May Be Predisposed to Various Cardiomyopathies.Novel long-range regulatory mechanisms controlling PKD2 gene expression.
P2860
Q24298048-5D23C8B7-5CF2-4CE8-AF75-3058870B2E11Q24305249-9AFBB093-4BCB-4342-93E2-1CB1D46E00D8Q24316336-A02DB048-82CE-44AF-80D3-2700057EED3CQ24318555-F88B37AD-4758-4283-BABC-8B47E9F6EA25Q24322255-E4F94A01-5549-447C-B612-84F1F57A3386Q27322406-507F5601-1405-42EB-A1A0-816E59AE7297Q28513693-DB5A7712-83E6-4FA6-B5CE-9704327C864FQ29616673-1FBCF7DC-A0C7-44C6-AFB1-BDFC7F0C11B0Q30492499-3672B584-B19C-4F12-BAB7-11AB4A9D95B1Q34339714-5FE3ABCE-3D80-4B26-B6BD-B8C7B54610D8Q34569800-72B2928D-1393-41D5-BAE4-2B5F73623CC0Q35112926-2FE74144-956B-4BD9-B813-ED45249B4C2FQ35362830-128D589E-3C1A-4D48-94ED-E10841C5D6E3Q35578913-8C66D3F2-C87E-4F0A-9868-BFF0ADDCA6FCQ36505469-54485C3D-EB12-4E6B-B5FF-457ACBFA5D0AQ36508601-245F42B9-846F-4BB6-BAAD-9662EE9CA5B7Q36670208-20F8158E-0192-44BF-B312-1E16123D6E4EQ36948959-55FC6809-9BA3-494D-9546-882B7C930FAEQ37086680-64D2CCCE-38FD-47E0-824B-EA59B70F524EQ37119771-04A1B6CD-C95F-44E6-965D-F9B07E1DE44CQ37264334-67DE1683-84FF-4B05-9D15-76ACBB4E51C7Q37430758-BCB7C436-64E1-4111-B497-05C717799F84Q37761966-7ED8BAC9-F7BC-4E9A-B0F6-80075C222A95Q38053059-A4564B07-3A9F-4028-849C-61FCBE327EE9Q38200953-747293FB-1045-412D-9603-E89A3FE378E6Q38279446-855C0F50-FA0C-48B5-8BA8-5D4986F0A29FQ38510714-F6D08277-76F3-4836-B12E-AEB77D782A89Q38628629-56345E58-3453-4095-9E36-6C8623FE7606Q39364250-6E55E25E-7B2C-4E68-BC43-C358CA3ECA9CQ39887478-B4ED96BE-C267-4C83-AB50-0DC12BD5297BQ40236601-4179C4BA-CAB3-4708-B41C-433A927EDD34Q40293601-EA1D024F-F2D3-4C65-A1A5-1B4B49E098FDQ40974288-6B58F6AB-0F2C-4BE7-A0B2-3C57DF32BC30Q41126514-436F4BF2-CDD9-46CA-92C9-912C0F57C4BFQ41888133-998224C2-A200-4ADD-879F-44C4D1327905Q41985398-2253231D-67E3-4D17-930D-ED11A363EB3CQ47101374-827CF347-6BAA-46EA-A551-A368DE61B34EQ55554153-47F3F81D-13FA-41F4-BBEC-847757503CF3
P2860
Alpha-actinin associates with polycystin-2 and regulates its channel activity
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@ast
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@en
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@en-gb
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@nl
type
label
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@ast
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@en
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@en-gb
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@nl
prefLabel
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@ast
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@en
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@en-gb
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@nl
P2093
P2860
P921
P356
P1476
Alpha-actinin associates with polycystin-2 and regulates its channel activity
@en
P2093
Christopher I Cheeseman
Edward Karpinski
Guanqing Wu
Horacio F Cantiello
Patrick Y Shen
Xiao-Qing Dai
Xing-Zhen Chen
P2860
P304
P356
10.1093/HMG/DDI167
P407
P577
2005-04-20T00:00:00Z