Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
about
Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatusStructural basis for Rab GTPase activation by VPS9 domain exchange factorsBIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integritySorting nexin 10 induces giant vacuoles in mammalian cellsThree myosin V structures delineate essential features of chemo-mechanical transductionThe Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN)Large nucleotide-dependent conformational change in Rab28Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factorsA COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factorPhosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK)Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the GolgiRational design of small molecule inhibitors targeting RhoA subfamily Rho GTPasesThe domain architecture of large guanine nucleotide exchange factors for the small GTP-binding protein ArfRegulation of small GTPases by GEFs, GAPs, and GDIsRegulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activationStructural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange FactorsStructure and Membrane Interaction of Myristoylated ARF13D structure of a binary ROP-PRONE complex: the final intermediate for a complete set of molecular snapshots of the RopGEF reactionIdentification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactionsDynamic structure of membrane-anchored Arf•GTPStructural basis for the specific inhibition of heterotrimeric Gq protein by a small moleculeGDP-bound and Nucleotide-free Intermediates of the Guanine Nucleotide Exchange in the Rab5{middle dot}Vps9 SystemStructure ofPlasmodium falciparumADP-ribosylation factor 1The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2A Novel Membrane Sensor Controls the Localization and ArfGEF Activity of Bacterial RalFDirect metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reactionRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p.Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p.ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal MelanomaDissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulenceHepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cellsAutomated NMR fragment based screening identified a novel interface blocker to the LARG/RhoA complexARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartmentModifications to the C-terminus of Arf1 alter cell functions and protein interactions.Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes
P2860
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P2860
Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structural snapshots of the me ...... ine nucleotide exchange factor
@ast
Structural snapshots of the me ...... ine nucleotide exchange factor
@en
Structural snapshots of the me ...... ine nucleotide exchange factor
@en-gb
Structural snapshots of the me ...... ine nucleotide exchange factor
@nl
type
label
Structural snapshots of the me ...... ine nucleotide exchange factor
@ast
Structural snapshots of the me ...... ine nucleotide exchange factor
@en
Structural snapshots of the me ...... ine nucleotide exchange factor
@en-gb
Structural snapshots of the me ...... ine nucleotide exchange factor
@nl
prefLabel
Structural snapshots of the me ...... ine nucleotide exchange factor
@ast
Structural snapshots of the me ...... ine nucleotide exchange factor
@en
Structural snapshots of the me ...... ine nucleotide exchange factor
@en-gb
Structural snapshots of the me ...... ine nucleotide exchange factor
@nl
P3181
P356
P1433
P1476
Structural snapshots of the me ...... ine nucleotide exchange factor
@en
P2093
Bernard Guibert
Louis Renault
P2888
P304
P3181
P356
10.1038/NATURE02197
P407
P577
2003-12-04T00:00:00Z
P5875
P6179
1052640420