The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN)
about
Regulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activationMolecular complexes that direct rhodopsin transport to primary ciliaRegulators and Effectors of Arf GTPases in NeutrophilsARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.Golgi compartmentation and identity.A three-stage model of Golgi structure and functionCell-specific establishment of poliovirus resistance to an inhibitor targeting a cellular protein.Role of Arf GTPases in fungal morphogenesis and virulenceRole of adaptor proteins in secretory granule biogenesis and maturationAllosteric regulation of Arf GTPases and their GEFs at the membrane interface.The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase.BIG1, a brefeldin A-inhibited guanine nucleotide-exchange factor, is required for GABA-gated Cl⁻ influx through regulation of GABAA receptor trafficking.CSFV proliferation is associated with GBF1 and Rab2.GBF/Gea mutant with a single substitution sustains fungal growth in the absence of BIG/Sec7.Four GTPases differentially regulate the Sec7 Arf-GEF to direct traffic at the trans-golgi network.The Arf GEF GBF1 and Arf4 synergize with the sensory receptor cargo, rhodopsin, to regulate ciliary membrane trafficking.BEN3/BIG2 ARF GEF is Involved in Brefeldin A-sensitive Trafficking at the trans-Golgi Network / Early Endosome in Arabidopsis thaliana.GBF1 and Arf1 function in vesicular trafficking, lipid homoeostasis and organelle dynamics.Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking.Bidirectional reporter assay using HAL promoter and TOPFLASH improves specificity in high-throughput screening of Wnt inhibitors.Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments.Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteins.The Arf activator GBF1 localizes to plasma membrane sites involved in cell adhesion and motility.The HUS-box is required for allosteric regulation of the Sec7 Arf-GEF.Cell-matrix adhesion controls Golgi organization and function through Arf1 activation in anchorage-dependent cells
P2860
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P2860
The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN)
description
2013 nî lūn-bûn
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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2013 թվականի ապրիլին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
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2013年論文
@zh-tw
2013年论文
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name
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@ast
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@en
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@en-gb
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@nl
type
label
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@ast
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@en
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@en-gb
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@nl
prefLabel
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@ast
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@en
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@en-gb
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@nl
P2093
P2860
P921
P356
P1476
The Sec7 guanine nucleotide ex ...... the trans-Golgi network (TGN)
@en
P2093
Elizabeth Sztul
Jason Lowery
Melanie Styers
Tomasz Szul
Zoe Holloway
P2860
P304
P356
10.1074/JBC.M112.438481
P407
P577
2013-04-19T00:00:00Z