PML colocalizes with and stabilizes the DNA damage response protein TopBP1
about
The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancersPML promotes MHC class II gene expression by stabilizing the class II transactivatorThe function, regulation and therapeutic implications of the tumor suppressor protein, PMLEDD mediates DNA damage-induced activation of CHK2Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia proteinAvicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid raftsND10 components relocate to sites associated with herpes simplex virus type 1 nucleoprotein complexes during virus infection.Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.Functional connection between Rad51 and PML in homology-directed repair.Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage respoThe proteins of intra-nuclear bodies: a data-driven analysis of sequence, interaction and expression.DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretionRelocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replicationSUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome.Cellular senescence and protein degradation: breaking down cancerPhosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.The role of post-translational modifications in fine-tuning BLM helicase function during DNA repairRapid and reliable confirmation of acute promyelocytic leukemia by immunofluorescence staining with an antipromyelocytic leukemia antibody: the M. D. Anderson Cancer Center experience of 349 patientsPML-mediated signaling and its role in cancer stem cells.The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence.Promyelocytic leukemia nuclear bodies support a late step in DNA double-strand break repair by homologous recombination.Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageingInteractions between DNA viruses, ND10 and the DNA damage response.Ubiquitin-dependent degradation of p73 is inhibited by PML.Multiple functions of rad9 for preserving genomic integrityTRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.Candidate protein biodosimeters of human exposure to ionizing radiation.PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL.Assembly of checkpoint and repair machineries at DNA damage sites.Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres.Defective DNA-damage repair induced by nuclear lamina dysfunction is a key mediator of smooth muscle cell aging.Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts.Components of promyelocytic leukemia nuclear bodies (ND10) act cooperatively to repress herpesvirus infection.A three-dimensional colocalization RNA interference screening platform to elucidate the alternative lengthening of telomeres pathway.Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 proteinSerotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins.Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression.The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.The acute promyelocytic leukaemia success story: curing leukaemia through targeted therapies.
P2860
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P2860
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@ast
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@en
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@en-gb
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@nl
type
label
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@ast
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@en
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@en-gb
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@nl
prefLabel
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@ast
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@en
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@en-gb
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@nl
P2093
P2860
P921
P3181
P1476
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
@en
P2093
Anna Timanova-Atanasova
Kun-Sang Chang
Rui-Xun Zhao
Zhi-Xiang Xu
P2860
P304
P3181
P356
10.1128/MCB.23.12.4247-4256.2003
P407
P577
2003-06-01T00:00:00Z