Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate
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Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ERSystematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networksProtein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processesFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisBuilding and remodelling Cullin-RING E3 ubiquitin ligasesA Dual E3 Mechanism for Rub1 Ligation to Cdc53Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding SurfaceA RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligasesSelective Recruitment of an E2 Ubiquitin Complex by an E3 Ubiquitin LigaseTwo Distinct Types of E3 Ligases Work in Unison to Regulate Substrate UbiquitylationThe ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activitySCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progressionPivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.Nutrient sensing kinases PKA and Sch9 phosphorylate the catalytic domain of the ubiquitin-conjugating enzyme Cdc34.The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylationTwists and turns in ubiquitin-like protein conjugation cascades.Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.Mechanisms of generating polyubiquitin chains of different topology.SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity.Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.Synergistic effect of two E2 ubiquitin conjugating enzymes in SCF(hFBH1) catalyzed polyubiquitination.Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1The HIP2~ubiquitin conjugate forms a non-compact monomeric thioester during di-ubiquitin synthesis.Substrate Ubiquitination Controls the Unfolding Ability of the Proteasome.An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases.Cellular strategies for making monoubiquitin signals.Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.Suramin inhibits cullin-RING E3 ubiquitin ligases.UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivoThe p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis.A snapshot of ubiquitin chain elongation: lysine 48-tetra-ubiquitin slows down ubiquitination.Ubiquitination of substrates by esterification.CRL Ubiquitin Ligases and DNA Damage Response.SCFs in the new millennium.
P2860
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P248
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P2860
Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@ast
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@en
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@en-gb
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@nl
type
label
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@ast
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@en
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@en-gb
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@nl
prefLabel
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@ast
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@en
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@en-gb
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@nl
P2093
P2860
P921
P3181
P1433
P1476
Priming and extending: a UbcH5 ...... quitination on a SCF substrate
@en
P2093
Jordan Kovacev
Kenneth Wu
Zhen-Qiang Pan
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2010.02.025
P407
P577
2010-03-26T00:00:00Z