Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2 - Wikidata - wikimedia - TriplyDB

Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2

Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2

http://www.wikidata.org/entity/Q24305064

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A novel GRK2/HDAC6 interaction modulates cell spreading and motility G protein-coupled receptor kinase 2 positively regulates epithelial cell migration Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5 Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism Targeting the ubiquitin-proteasome system in heart disease: the basis for new therapeutic strategies Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2 Screening E3 substrates using a live phage display library β-Arrestin-mediated receptor trafficking and signal transduction Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways G protein-coupled receptor kinases: more than just kinases and not only for GPCRs Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity Seven-transmembrane receptors and ubiquitination Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death.beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53.The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival.Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model Coping with stress: multiple ways to activate p53.MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment.Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2 Adrenergic signaling and oxidative stress: a role for sirtuins?Degradation of activated protein kinases by ubiquitination.Proteasome inhibition during myocardial infarction.G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets Heterogeneous cardiac proteasomes: mandated by diverse substrates?G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance.Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overproliferation and deletion G protein-coupled receptor kinase 2 promotes cardiac hypertrophy Ubiquitin-Related Roles of β-Arrestins in Endocytic Trafficking and Signal Transduction.Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals GRK2 negatively regulates IGF-1R signaling pathway and cyclins' expression in HepG2 cells.Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation

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Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2

http://www.wikidata.org/entity/Q24305064

description

2006 nî lūn-bûn

@nan

2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@ast

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@en

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@en-gb

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@nl

type

label

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@ast

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@en

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@en-gb

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@nl

prefLabel

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@ast

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@en

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@en-gb

Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@nl

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SJ.EMBOJ.7601351

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The EMBO Journal

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Mdm2 is involved in the ubiqui ...... tein-coupled receptor kinase 2

@en

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Alicia Salcedo

http://www.w3.org/2001/XMLSchema#string

Federico Mayor

http://www.w3.org/2001/XMLSchema#string

Petronila Penela

http://www.w3.org/2001/XMLSchema#string

P2860

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase

Mechanisms underlying ubiquitination

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

Themes and variations on ubiquitylation

Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2

Posttranslational modification of MDM2

Transduction of receptor signals by beta-arrestins

Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2

Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling

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4752-62

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scholarly article

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5024863

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10.1038/SJ.EMBOJ.7601351

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20

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25

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2006-10-18T00:00:00Z

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6787212

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17006543

http://www.w3.org/2001/XMLSchema#string

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protein ubiquitination

G protein-coupled receptor

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1618114

http://www.w3.org/2001/XMLSchema#string