The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets
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Migration of Th1 lymphocytes is regulated by CD152 (CTLA-4)-mediated signaling via PI3 kinase-dependent Akt activationG protein-coupled receptor kinase 2 promotes flaviviridae entry and replicationA novel GRK2/HDAC6 interaction modulates cell spreading and motilityGRK2: multiple roles beyond G protein-coupled receptor desensitizationG-protein-coupled receptor kinase 2 and endothelial dysfunction: molecular insights and pathophysiological mechanismsTrafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localizationG protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism"Freeze, Don't Move": How to Arrest a Suspect in Heart Failure - A Review on Available GRK2 InhibitorsG protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure.Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling.Regulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain.Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2S-nitrosylation-regulated GPCR signaling.G protein coupled receptor kinases as therapeutic targets in cardiovascular disease.Technical phosphoproteomic and bioinformatic tools useful in cancer research.Monitoring of phosphorylated peptides by radioactive assay and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry.Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.RGS9-2--controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states.Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptorsProtein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector.TLR4 Signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation.A peptide of the RGS domain of GRK2 binds and inhibits Gα(q) to suppress pathological cardiac hypertrophy and dysfunction.Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2GRK3 is essential for metastatic cells and promotes prostate tumor progression.GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells.G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 AxisAn essential role for Grk2 in Hedgehog signalling downstream of Smoothened.Targeted gene therapy for the treatment of heart failure.G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance.G protein-coupled receptor kinases in normal and failing myocardium.A role for GRK2 in myocardial ischemic injury: indicators of a potential future therapy and diagnostic.Biochemical and molecular aspects of vascular adrenergic regulation of blood pressure in the elderlyThe connection between GRKs and various signaling pathways involved in diabetic nephropathy.Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overproliferation and deletionTargeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapyHeart failure-specific changes in protein kinase signalling.Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice.G protein-coupled receptor kinase 2 promotes cardiac hypertrophy
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The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The complex G protein-coupled ...... new physiopathological targets
@en
The complex G protein-coupled receptor kinase 2
@nl
type
label
The complex G protein-coupled ...... new physiopathological targets
@en
The complex G protein-coupled receptor kinase 2
@nl
prefLabel
The complex G protein-coupled ...... new physiopathological targets
@en
The complex G protein-coupled receptor kinase 2
@nl
P2093
P2860
P1476
The complex G protein-coupled ...... new physiopathological targets
@en
P2093
Catalina Ribas
Cristina Murga
Federico Mayor
Petronila Penela
Vanesa Lafarga
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P304
P356
10.1111/J.1476-5381.2010.00727.X
P407
P577
2010-06-01T00:00:00Z