CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors
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Function Over Form: Modeling Groups of Inherited Neurological Conditions in ZebrafishPrenatal Neurogenesis in Autism Spectrum DisordersMutations and Modeling of the Chromatin Remodeler CHD8 Define an Emerging Autism EtiologyGenetics and genomics of psychiatric diseaseFunctional Insights into Chromatin Remodelling from Studies on CHARGE SyndromeChromodomain helicase DNA-binding proteins in stem cells and human developmental diseasesAdvancing the understanding of autism disease mechanisms through geneticsWnt signaling networks in autism spectrum disorder and intellectual disabilitySMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome.Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signalingToddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers.Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal CircuitsTranscriptional role of androgen receptor in the expression of long non-coding RNA Sox2OT in neurogenesis.Polycomb and trithorax opposition in development and disease.The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopmentInsights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies.ZNF804A Transcriptional Networks in Differentiating Neurons Derived from Induced Pluripotent Stem Cells of Human OriginRbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly.The chromatin Remodeler CHD8 is required for activation of progesterone receptor-dependent enhancers.Epigenetic changes in the developing brain: Effects on behavior.The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genesCRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment.Genetics and genomics of autism spectrum disorder: embracing complexity.Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders.Diffusion Tensor Imaging Provides Evidence of Possible Axonal Overconnectivity in Frontal Lobes in Autism Spectrum Disorder Toddlers.Reduced CYFIP1 in Human Neural Progenitors Results in Dysregulation of Schizophrenia and Epilepsy Gene Networks.Genome-wide variant analysis of simplex autism families with an integrative clinical-bioinformatics pipeline.Transcriptomics analysis of iPSC-derived neurons and modeling of neuropsychiatric disorders.Potential molecular consequences of transgene integration: The R6/2 mouse example.The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies.CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells.The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer.Regulation of nucleosome positioning by a CHD Type III chromatin remodeler and its relationship to developmental gene expression in DictyosteliumMaternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder.Recent advances in the genetics of autism spectrum disorder.Strength of functional signature correlates with effect size in autism.ChIP-seq in studying epigenetic mechanisms of disease and promoting precision medicine: progresses and future directions.ATP-dependent chromatin remodeling during mammalian development.Early brain development in infants at high risk for autism spectrum disorder.
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P2860
CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
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2014年学术文章
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2014年學術文章
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name
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@ast
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@en
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@en-gb
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@nl
type
label
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@ast
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@en
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@en-gb
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@nl
prefLabel
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@ast
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@en
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@en-gb
CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@nl
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P50
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CHD8 regulates neurodevelopmen ...... disorder in neural progenitors
@en
P2093
Aarathi Sugathan
Alexei Stortchevoi
Ashok Ragavendran
Diane Lucente
Harrison Brand
Ian Blumenthal
Judith Miles
Poornima Manavalan
Steven D Sheridan
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P304
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10.1073/PNAS.1405266111
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P577
2014-10-21T00:00:00Z