DNA end resection by CtIP and exonuclease 1 prevents genomic instability
about
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repairDNA End Resection: Facts and MechanismsDNA double-strand break repair pathway choice and cancerCross talk between the nuclease and helicase activities of Dna2: role of an essential iron-sulfur cluster domainCompeting roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resectionBRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous RecombinationGenome-wide identification of CBX2 targets: insights in the human sex development network.Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.CtIP-mediated resection is essential for viability and can operate independently of BRCA1.CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair.Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1.CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.Mutations in the BRCT binding site of BRCA1 result in hyper-recombinationEnd resection at double-strand breaks: mechanism and regulation.RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.DNA end resection--unraveling the tail.APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage.Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeresReplication fork integrity and intra-S phase checkpoint suppress gene amplification.14-3-3 proteins restrain the Exo1 nuclease to prevent overresection.Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisionsSingle-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joiningCtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 CellsHuman exonuclease 1 (EXO1) activity characterization and its function on flap structures.Sumoylation regulates EXO1 stability and processing of DNA damage.DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network.MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts.Controlling DNA-end resection: a new task for CDKs.It takes two to tango: Ubiquitin and SUMO in the DNA damage response.Sharpening the ends for repair: mechanisms and regulation of DNA resection.Mechanism and regulation of DNA end resection in eukaryotesPCNA promotes processive DNA end resection by Exo1.Dual mode of cell death upon the photo-irradiation of a RuII polypyridyl complex in interphase or mitosis.
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P2860
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@ast
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@en
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@en-gb
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@nl
type
label
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@ast
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@en
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@en-gb
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@nl
prefLabel
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@ast
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@en
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@en-gb
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@nl
P2093
P2860
P50
P3181
P356
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P1476
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
@en
P2093
Christiane König
Javier Peña-Diaz
Lorenza P Ferretti
Mahmoud El-Shemerly
Martin Steger
Wassim Eid
P2860
P3181
P356
10.1038/EMBOR.2010.157
P407
P577
2010-12-01T00:00:00Z