Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. - Wikidata - wikimedia - TriplyDB

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.

http://www.wikidata.org/entity/Q33697447

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Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site Controlling DNA-End Resection: An Emerging Task for Ubiquitin and SUMO Replication fork instability and the consequences of fork collisions from rereplication Replication stress in Mammalian cells and its consequences for mitosis A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Immunofluorescence-based methods to monitor DNA end resection.A role for nuclear envelope-bridging complexes in homology-directed repair.DNA double-strand break repair: a tale of pathway choices.S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci.Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein.14-3-3 proteins restrain the Exo1 nuclease to prevent overresection.International Differences in Treatment and Clinical Outcomes for High Grade Glioma Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.Biochemical mechanism of DSB end resection and its regulation.Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.Sumoylation regulates EXO1 stability and processing of DNA damage.NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres.Single-molecule motions and interactions in live cells reveal target search dynamics in mismatch repair.MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts.Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection.Repair Pathway Choices and Consequences at the Double-Strand Break Role of the double-strand break repair pathway in the maintenance of genomic stability.Sharpening the ends for repair: mechanisms and regulation of DNA resection.Mechanism and regulation of DNA end resection in eukaryotes CDK1 phosphorylates WRN at collapsed replication forks.Endonuclease EEPD1 Is a Gatekeeper for Repair of Stressed Replication Forks Augmented HR Repair Mediates Acquired Temozolomide Resistance in Glioblastoma.The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.Exonuclease 1 and its versatile roles in DNA repair.The control of DNA repair by the cell cycle.Small-molecule binding sites to explore protein-protein interactions in the cancer proteome.Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities.BRCA1 loses the ring but lords over resistance.Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection.Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.Roscovitine strongly enhances the effect of olaparib on radiosensitivity for HPV neg. but not for HPV pos. HNSCC cell lines.ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair.Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy.

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Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.

http://www.wikidata.org/entity/Q33697447

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2014 nî lūn-bûn

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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2014 թվականի ապրիլին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Phosphorylation of EXO1 by CDK ...... ion and repair pathway choice.

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Phosphorylation of EXO1 by CDK ...... ion and repair pathway choice.

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Phosphorylation of EXO1 by CDK ...... ion and repair pathway choice.

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Phosphorylation of EXO1 by CDK ...... ion and repair pathway choice.

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Phosphorylation of EXO1 by CDK ...... ion and repair pathway choice.

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Phosphorylation of EXO1 by CDK ...... ion and repair pathway choice.

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Nature Communications

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Phosphorylation of EXO1 by CDK ...... ion and repair pathway choice.

@en

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Bertrand Llorente

http://www.w3.org/2001/XMLSchema#string

Bipasha Mukherjee

http://www.w3.org/2001/XMLSchema#string

Cristel Vanessa Camacho

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Janelle Louise Harris

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Kum Kum Khanna

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Mariya Ilcheva

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Matthew Porteus

http://www.w3.org/2001/XMLSchema#string

Molly Catherine Hardebeck

http://www.w3.org/2001/XMLSchema#string

Nozomi Tomimatsu

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Sandeep Burma

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P2860

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

DNA end resection by CtIP and exonuclease 1 prevents genomic instability

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

CDK targets Sae2 to control DNA-end resection and homologous recombination

DNA resection in eukaryotes: deciding how to fix the break

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing.

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation.

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10.1038/NCOMMS4561

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5

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2014-04-07T00:00:00Z

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1008266362

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24705021

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phosphorylation

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4041212

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