Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2
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Evolution of the holozoan ribosome biogenesis regulonChemogenomic approach identified yeast YLR143W as diphthamide synthetaseStructure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4Haploid genetic screens in human cells identify host factors used by pathogensDiphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzymeComparative proteogenomics: combining mass spectrometry and comparative genomics to analyze multiple genomesDiphthamide modification of eEF2 requires a J-domain protein and is essential for normal developmentThe diphthamide modification pathway from Saccharomyces cerevisiae--revisitedStructural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modificationYBR246W is required for the third step of diphthamide biosynthesisRibosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans.Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance.Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis.The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction networkHunting Viral Receptors Using Haploid CellsLoss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factorThe biosynthesis and biological function of diphthamideA dominant-negative approach that prevents diphthamide formation confers resistance to Pseudomonas exotoxin A and diphtheria toxinIdentification of host cell factors required for intoxication through use of modified cholera toxinA genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiaeIdentification of ENA1 as a virulence gene of the human pathogenic fungus Cryptococcus neoformans through signature-tagged insertional mutagenesisQuantitative high-throughput screening identifies inhibitors of anthrax-induced cell deathCharacterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2.Reconstitution of diphthine synthase activity in vitro.Metabolome and proteome changes with aging in Caenorhabditis elegans.Evolutionary Conservation and Emerging Functional Diversity of the Cytosolic Hsp70:J Protein Chaperone Network of Arabidopsis thalianaAllele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegansSilencing of diphthamide synthesis 3 (Dph3) reduces metastasis of murine melanoma.A 556 kb deletion in the downstream region of the PAX6 gene causes familial aniridia and other eye anomalies in a Chinese family.Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse developmentA guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer.Characterization of Cholix toxin-induced apoptosis in HeLa cells.Ethanolamine phosphoglycerol attachment to eEF1A is not essential for normal growth of Trypanosoma bruceiNetwork of general and specialty J protein chaperones of the yeast cytosolThe elongation, termination, and recycling phases of translation in eukaryotes.Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse developmentMatrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculatureCharacterization of the interaction between anthrax toxin and its cellular receptorsThe diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin.
P2860
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P2860
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2
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2004 nî lūn-bûn
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2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年學術文章
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Identification of the proteins ...... ranslation elongation factor 2
@ast
Identification of the proteins ...... ranslation elongation factor 2
@en
Identification of the proteins ...... ranslation elongation factor 2
@en-gb
Identification of the proteins ...... ranslation elongation factor 2
@nl
type
label
Identification of the proteins ...... ranslation elongation factor 2
@ast
Identification of the proteins ...... ranslation elongation factor 2
@en
Identification of the proteins ...... ranslation elongation factor 2
@en-gb
Identification of the proteins ...... ranslation elongation factor 2
@nl
prefLabel
Identification of the proteins ...... ranslation elongation factor 2
@ast
Identification of the proteins ...... ranslation elongation factor 2
@en
Identification of the proteins ...... ranslation elongation factor 2
@en-gb
Identification of the proteins ...... ranslation elongation factor 2
@nl
P2093
P2860
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P1476
Identification of the proteins ...... ranslation elongation factor 2
@en
P2093
G Todd Milne
Gerald R Fink
Jeffrey G Kuremsky
P2860
P304
P3181
P356
10.1128/MCB.24.21.9487-9497.2004
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P577
2004-11-01T00:00:00Z