Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions
about
Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) proteinNegative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motilityPyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesionsTyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactinDirect binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activationRegulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascadeInteraction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signalingThe phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor proteinIntroduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinasesConstitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynaminCell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesionsRIC, a calmodulin-binding Ras-like GTPaseTWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structureTyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substratesA calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signalAssociation of Src tyrosine kinase with a human potassium channel mediated by SH3 domainPyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreadingEvidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinasesHuman immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells.Regulation of focal adhesion kinase by a novel protein inhibitor FIP200The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinaseReceptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activityInterferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytesNir2, a novel regulator of cell morphogenesisHic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinaseIdentification of a new Pyk2 target protein with Arf-GAP activityRequirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathwaysThe heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytesA mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brainActivation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffoldsTRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltrationMitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascadeFibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteinsIdentification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST.Janus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transductionTyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signalingRAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes
P2860
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P2860
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@ast
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@en
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@en-gb
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@nl
type
label
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@ast
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@en
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@en-gb
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@nl
prefLabel
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@ast
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@en
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@en-gb
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@nl
P2093
P3181
P356
P1433
P1476
Protein tyrosine kinase PYK2 i ...... annel and MAP kinase functions
@en
P2093
G D Plowman
J M Musacchio
J Schlessinger
R Martinez
P2888
P304
P3181
P356
10.1038/376737A0
P407
P577
1995-08-31T00:00:00Z
P5875
P6179
1030681157