A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain
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The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cellsSequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domainThe neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter moleculesTwo adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinaseBrain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neuronsShcB and ShcC activation by the Trk family of receptor tyrosine kinasesActivation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell linesDomain-specific function of ShcC docking protein in neuroblastoma cellsRAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumorsN-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signalingLinkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependenceInteraction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteinsAnalysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinaseCellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor proteinDifferential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairmentThe ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryoNon-redundant role of Shc in Erk activation by cytoskeletal reorganizationShc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytesSck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling.Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice.Biological role of anaplastic lymphoma kinase in neuroblastoma.The function of the neuronal proteins Shc and huntingtin in stem cells and neurons: pharmacologic exploitation for human brain diseases.Expression and activation of SH2/PTB-containing ShcA adaptor protein reflects the pattern of neurogenesis in the mammalian brain.Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor-Mediated Signaling in NeuroblastomaBinding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response.The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway.Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development.The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia.The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor.Teaching an old dogma new tricks: twenty years of Shc adaptor signalling.Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1.Distinct role of ShcC docking protein in the differentiation of neuroblastoma.The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor.The role of the Shc phosphotyrosine interaction/phosphotyrosine binding domain and tyrosine phosphorylation sites in polyoma middle T antigen-mediated cell transformation.Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling.Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules.Comparative expression profiles of Trk receptors and Shc-related phosphotyrosine adapters during retinal development: potential roles of N-Shc/ShcC in brain-derived neurotrophic factor signal transduction and modulation.Deletion of the ageing gene p66(Shc) reduces early stroke size following ischaemia/reperfusion brain injury.
P2860
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P2860
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain
description
1996 nî lūn-bûn
@nan
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
A mammalian adaptor protein wi ...... fically expressed in the brain
@ast
A mammalian adaptor protein wi ...... fically expressed in the brain
@en
A mammalian adaptor protein wi ...... fically expressed in the brain
@nl
type
label
A mammalian adaptor protein wi ...... fically expressed in the brain
@ast
A mammalian adaptor protein wi ...... fically expressed in the brain
@en
A mammalian adaptor protein wi ...... fically expressed in the brain
@nl
prefLabel
A mammalian adaptor protein wi ...... fically expressed in the brain
@ast
A mammalian adaptor protein wi ...... fically expressed in the brain
@en
A mammalian adaptor protein wi ...... fically expressed in the brain
@nl
P2093
P2860
P356
P1476
A mammalian adaptor protein wi ...... fically expressed in the brain
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.7.2729
P407
P577
1996-04-02T00:00:00Z