Characterization of Pellino2, a substrate of IRAK1 and IRAK4
about
The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligasesInterleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinasePellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferonsPellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitisBCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner.Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancerPellino proteins: novel players in TLR and IL-1R signallingIdentification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins.Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance.The roles of Pellino E3 ubiquitin ligases in immunity.Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity.E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses.Molecular mechanisms of regulation of Toll-like receptor signalingA poxviral homolog of the Pellino protein inhibits Toll and Toll-like receptor signalling.IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).Fine tuning of RFX/DAF-19-regulated target gene expression through binding to multiple sites in Caenorhabditis elegans.The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.Alternate transcription of the Toll-like receptor signaling cascade.Crystal structure of human IRAK1.Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins.The role of TBK1 and IKKε in the expression and activation of Pellino 1.hp-IRAK1;hp-IRAK4 bind Pellino1;2;3hp-IRAK1; hp-IRAK4 4 phosphorylate Pellino-1 and 2.The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome.
P2860
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P2860
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@ast
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@en
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@en-gb
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@nl
type
label
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@ast
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@en
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@en-gb
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@nl
prefLabel
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@ast
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@en
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@en-gb
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@nl
P2093
P2860
P1433
P1476
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
@en
P2093
Astrid Strelow
Christian Kollewe
Holger Wesche
P2860
P304
P356
10.1016/S0014-5793(03)00697-5
P407
P577
2003-07-17T00:00:00Z