Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks
about
Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium releaseIn cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin bindingDysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseasesThe ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisisInherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesisFRET detection of calmodulin binding to the cardiac RyR2 calcium release channelCaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors.Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmiasJunctional cleft [Ca²⁺]i measurements using novel cleft-targeted Ca²⁺ sensorsFKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.Sex-dependent, zinc-induced dephosphorylation of phospholamban by tissue-nonspecific alkaline phosphatase in the cardiac sarcomereEpac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.FRET-based trilateration of probes bound within functional ryanodine receptors.Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice.A-kinase anchoring proteins: scaffolding proteins in the heart.Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6.Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.Ultrastructural Analysis of Self-Associated RyR2sA mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment.N-terminal and central segments of the type 1 ryanodine receptor mediate its interaction with FK506-binding proteinsCalcium Sparks in the Heart: Dynamics and Regulation.Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cellsIn vitro studies of early cardiac remodeling: impact on contraction and calcium handling.Molecular Mechanisms of Increased Heart Rate in Shenxianshengmai-treated Bradycardia Rabbits.Ca handling during excitation-contraction coupling in heart failure.Cardiac gene therapy with SERCA2a: from bench to bedsideRefilling Intracellular Calcium Stores.Calcium signaling in cardiac myocytes.Inherited calcium channelopathies in the pathophysiology of arrhythmias.Ryanodine receptor calcium release channels: lessons from structure-function studies.The sarcoplasmic reticulum and the evolution of the vertebrate heart.The ryanodine receptor provides high throughput Ca2+-release but is precisely regulated by networks of associated proteins: a focus on proteins relevant to phosphorylation.Total internal reflectance fluorescence imaging of genetically engineered ryanodine receptor-targeted Ca2+ probes in rat ventricular myocytes.FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge.The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.Mechanisms of SR calcium release in healthy and failing human hearts.Calcium and Excitation-Contraction Coupling in the Heart
P2860
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P2860
Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@ast
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@en
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@en-gb
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@nl
type
label
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@ast
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@en
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@en-gb
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@nl
prefLabel
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@ast
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@en
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@en-gb
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@nl
P2093
P2860
P921
P1433
P1476
Kinetics of FKBP12.6 binding t ...... cytes and effects on Ca sparks
@en
P2093
Bradley R Fruen
Eckard Picht
Emmanuel Camors
Sabine Huke
P2860
P304
P356
10.1161/CIRCRESAHA.110.219816
P407
P577
2010-04-29T00:00:00Z