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Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ releaseThe deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failureIn cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin bindingKinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparksCa2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sitesRole of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heartThe inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger functionNa+ channel function, regulation, structure, trafficking and sequestrationCa(2+) current facilitation is CaMKII-dependent and has arrhythmogenic consequencesTargets for therapy in sarcomeric cardiomyopathiesFormation of spatially discordant alternans due to fluctuations and diffusion of calciumRole of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death.Calcium and cardiac rhythms: physiological and pathophysiologicalA critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac functionNa+/Ca2+ exchange and Na+/K+-ATPase in the heartAbnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cellsPost-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmiasA cardiac dihydropyridine receptor II-III loop peptide inhibits resting Ca(2+) sparks in ferret ventricular myocytesSparkMaster: automated calcium spark analysis with ImageJEpac enhances excitation-transcription coupling in cardiac myocytesHistidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac functionPhospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytesLocation matters: clarifying the concept of nuclear and cytosolic CaMKII subtypesFRET detection of calmodulin binding to the cardiac RyR2 calcium release channelNitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanismCalmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytesRole of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase.Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman.Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during beta-adrenergic stimulation in mouse ventricular myocytes.Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytesDifferential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes.Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient miceThe human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPaseScreening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays.Bay K 8644 increases resting Ca2+ spark frequency in ferret ventricular myocytes independent of Ca influx: contrast with caffeine and ryanodine effects.BayK 8644 increases resting calcium spark frequency in ferret ventricular myocytes.Confocal imaging of CICR events from isolated and immobilized SR vesicles.Temperature-dependent activation of neurons by continuous near-infrared laserPhospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice
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description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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Donald M Bers
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Donald M Bers
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Donald M Bers
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Donald M Bers
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Donald M Bers
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Donald M Bers
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Donald M Bers
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Donald M Bers
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Donald M Bers
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Donald M Bers
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Donald M Bers
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Donald M Bers
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P108
P106
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P3835
donald-bers
P496
0000-0002-2237-9483