Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome
about
TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradationATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complexProteins associated with the exon junction complex also control the alternative splicing of apoptotic regulatorsAly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNAInterferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNAGenome-wide comprehensive analysis of human helicasesThe organization and contribution of helicases to RNA splicingFunctional roles of DExD/H-box RNA helicases in Pre-mRNA splicingRNA helicases in splicingSplicing fidelity: DEAD/H-box ATPases as molecular clocksCoupling pre-mRNA processing to transcription on the RNA factory assembly lineRNA helicase proteins as chaperones and remodelersThe role of TREX in gene expression and diseaseArabidopsis DEAD-box RNA helicase UAP56 interacts with both RNA and DNA as well as with mRNA export factorsUAP56 is a novel interacting partner of Bcr in regulating vascular smooth muscle cell DNA synthesisUAP56 is an important mediator of angiotensin II/platelet derived growth factor induced vascular smooth muscle cell DNA synthesis and proliferationUAP56 is an important regulator of protein synthesis and growth in cardiomyocytesSpliceosome Structure and FunctionThe closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progressionThe cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity.Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57.Stem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly.The cellular RNA helicase UAP56 is required for prevention of double-stranded RNA formation during influenza A virus infectionExon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8A role for TREX components in the release of spliced mRNA from nuclear speckle domains.Interactome for auxiliary splicing factor U2AF(65) suggests diverse roles.Polypyrimidine tract binding protein inhibits IgM pre-mRNA splicing by diverting U2 snRNA base-pairing away from the branch point.The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.Multiple factors in the early splicing complex are involved in the nuclear retention of pre-mRNAs in mammalian cells.Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection.Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.A dual reporter approach to quantify defects in messenger RNA processingHuman Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.DExD/H-box Prp5 protein is in the spliceosome during most of the splicing cycle.The transition in spliceosome assembly from complex E to complex A purges surplus U1 snRNPs from alternative splice sites.Heat shock factor 4 regulates the expression of HSP25 and alpha B-crystallin by associating with DEXD/H-box RNA helicase UAP56.The Arabidopsis THO/TREX component TEX1 functionally interacts with MOS11 and modulates mRNA export and alternative splicing events.The Cellular DExD/H-Box RNA Helicase UAP56 Co-localizes With the Influenza A Virus NS1 ProteinOverlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF
P2860
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P2860
Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Distinct activities of the DEx ...... se assembly of the spliceosome
@ast
Distinct activities of the DEx ...... se assembly of the spliceosome
@en
Distinct activities of the DEx ...... se assembly of the spliceosome
@en-gb
Distinct activities of the DEx ...... se assembly of the spliceosome
@nl
type
label
Distinct activities of the DEx ...... se assembly of the spliceosome
@ast
Distinct activities of the DEx ...... se assembly of the spliceosome
@en
Distinct activities of the DEx ...... se assembly of the spliceosome
@en-gb
Distinct activities of the DEx ...... se assembly of the spliceosome
@nl
prefLabel
Distinct activities of the DEx ...... se assembly of the spliceosome
@ast
Distinct activities of the DEx ...... se assembly of the spliceosome
@en
Distinct activities of the DEx ...... se assembly of the spliceosome
@en-gb
Distinct activities of the DEx ...... se assembly of the spliceosome
@nl
P2093
P2860
P3181
P356
P1433
P1476
Distinct activities of the DEx ...... se assembly of the spliceosome
@en
P2093
Haihong Shen
Jingping Shen
Lingdi Zhang
Michael R Green
Xuexiu Zheng
P2860
P304
P3181
P356
10.1101/GAD.1657308
P407
P577
2008-07-01T00:00:00Z