A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
about
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressPancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stressThe novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathwayATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1Identification of a novel thioredoxin-related transmembrane proteinIdentification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein responseActivation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stressDimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stressStructure of the Ire1 autophosphorylation complex and implications for the unfolded protein responseA crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cellsStructure and intermolecular interactions of the luminal dimerization domain of human IRE1alphaA synthetic biology approach identifies the mammalian UPR RNA ligase RtcBpXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseHuman HRD1 protects against ER stress-induced apoptosis through ER-associated degradationActivation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stressBasis for regulated RNA cleavage by functional analysis of RNase L and Ire1pAlternative function of a protein kinase homology domain in 2', 5'-oligoadenylate dependent RNase LIdentification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myelomaDivergent allosteric control of the IRE1α endoribonuclease using kinase inhibitorsPotent and selective inhibitors of the inositol-requiring enzyme 1 endoribonucleaseConserved RNA structures in the non-canonical Hac1/Xbp1 intronNrf2 is a direct PERK substrate and effector of PERK-dependent cell survivalIRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseJapanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein responseGenome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nucleaseGenetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.The unfolded protein response: the dawn of a new fieldThe unfolded protein response in neurodegenerative diseases: a neuropathological perspectiveRole of endoplasmic reticulum stress and autophagy as interlinking pathways in the pathogenesis of inflammatory bowel diseaseThe unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein foldingDrosophila as a model for unfolded protein response researchEndoplasmic reticulum stress and type 2 diabetesXenobiotic perturbation of ER stress and the unfolded protein responseThe unfolded protein response and diabetic retinopathyEndoplasmic reticulum stress and diabetic cardiomyopathyXBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death.Flavivirus Infection Activates the XBP1 Pathway of the Unfolded Protein Response To Cope with Endoplasmic Reticulum StressStructure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitorsCrystal Structure of a"Nonfoldable"Insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITYFlavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1
P2860
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P2860
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@ast
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@en
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@en-gb
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@nl
type
label
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@ast
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@en
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@en-gb
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@nl
prefLabel
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@ast
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@en
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@en-gb
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@nl
P2860
P921
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P1476
A stress response pathway from ...... ase (Ire1p) in mammalian cells
@en
P2093
R J Kaufman
W Tirasophon
P2860
P304
P3181
P356
10.1101/GAD.12.12.1812
P407
P577
1998-06-01T00:00:00Z