Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors - Wikidata - wikimedia - TriplyDB

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

http://www.wikidata.org/entity/Q27640568

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The unfolded protein response in neurodegenerative diseases: a neuropathological perspective Drugging the unfolded protein response in acute leukemias Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment Molecular mechanisms of human IRE1 activation through dimerization and ligand binding Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.Druggable sensors of the unfolded protein response.Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases.Targeting the unfolded protein response for disease intervention.Targeting endoplasmic reticulum stress in liver disease.Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic.The rise of proteostasis promoters.Endoplasmic reticulum proteostasis: a key checkpoint in cancer.Targeting the unfolded protein response in cancer.Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.Physiological/pathological ramifications of transcription factors in the unfolded protein response.The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease.Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia.Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling.Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.Expression of XBP1s in fibroblasts is critical for TiAl6 V4 particle-induced RANKL expression and osteolysis.Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein

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Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

http://www.wikidata.org/entity/Q27640568

description

2014 nî lūn-bûn

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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2014 թվականի օգոստոսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Structure and mechanism of act ...... E1 endoribonuclease inhibitors

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Structure and mechanism of act ...... E1 endoribonuclease inhibitors

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Structure and mechanism of act ...... E1 endoribonuclease inhibitors

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Structure and mechanism of act ...... E1 endoribonuclease inhibitors

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Structure and mechanism of act ...... E1 endoribonuclease inhibitors

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Structure and mechanism of act ...... E1 endoribonuclease inhibitors

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Structure and mechanism of act ...... E1 endoribonuclease inhibitors

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Structure and mechanism of act ...... E1 endoribonuclease inhibitors

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Nature Communications

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Structure and mechanism of act ...... E1 endoribonuclease inhibitors

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Andras Toro

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Brian Wilson

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Colleen Schweitzer

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Danka Vuga

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David Chiovitti

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David Uehling

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Gennadiy Poda

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Igor Kurinov

http://www.w3.org/2001/XMLSchema#string

John B Patterson

http://www.w3.org/2001/XMLSchema#string

Julie L Lucas

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P2860

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

Plasma cell differentiation requires the transcription factor XBP-1

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

The unfolded protein response: integrating stress signals through the stress sensor IRE1α

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

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4202

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10.1038/NCOMMS5202

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5

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Daniel Durocher

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2014-08-28T00:00:00Z

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265134073

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1029146019

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