Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
about
Phosphorylation at serine 331 is required for Aurora B activation.Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1.Kinetochore-microtubule interactions: steps towards bi-orientationAbscission checkpoint control: stuck in the middle with Aurora BThe Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint SignalingAurora B hyperactivation by Bub1 overexpression promotes chromosome missegregationReconstituting the kinetochore–microtubule interface: what, why, and howAurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindleChromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomesARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochoresSelective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytesCrystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125Small-molecule kinase inhibitors provide insight into Mps1 cell cycle functionSelective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity ScreenA TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora BMimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signallingChemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosisHigh-content, high-throughput analysis of cell cycle perturbations induced by the HSP90 inhibitor XL888Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1A Centromere-Signaling Network Underlies the Coordination among Mitotic EventsConnecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.A link between aurora kinase and Clp1/Cdc14 regulation uncovered by the identification of a fission yeast borealin-like protein.High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.Mps1 promotes rapid centromere accumulation of Aurora B.MLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with BorealinCharacterization of novel MPS1 inhibitors with preclinical anticancer activityThe spindle assembly checkpoint works like a rheostat rather than a toggle switchChk2 prevents mitotic exit when the majority of kinetochores are unattached.Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view.Aurora kinases: novel therapy targets in cancersThe MPS1 family of protein kinases.AURKA mRNA expression is an independent predictor of poor prognosis in patients with non-small cell lung cancerN-terminal regions of Mps1 kinase determine functional bifurcation.Mps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis.Finding the middle ground: how kinetochores power chromosome congression.Chromatin protein HP1 interacts with the mitotic regulator borealin protein and specifies the centromere localization of the chromosomal passenger complexDissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversineMps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.
P2860
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P2860
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@ast
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@en
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@en-gb
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@nl
type
label
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@ast
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@en
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@en-gb
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@nl
prefLabel
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@ast
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@en
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@en-gb
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@nl
P2093
P3181
P1433
P1476
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
@en
P2093
Arjan B Brenkman
Carin W A Cruijsen
Maria H J van Osch
Nannette Jelluma
Niels J F van den Broek
Susanne M A Lens
P304
P3181
P356
10.1016/J.CELL.2007.11.046
P407
P577
2008-01-01T00:00:00Z