NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
about
Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progressionNiemann-Pick disease type CLoss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomesNovel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 proteinNogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol traffickingAutophagy in lysosomal storage disordersEbola virus entry requires the host-programmed recognition of an intracellular receptorDeficiency of niemann-pick type C-1 protein impairs release of human immunodeficiency virus type 1 and results in Gag accumulation in late endosomal/lysosomal compartmentsNPC1/NPC2 function as a tag team duo to mobilize cholesterolThe LDL receptorMolecular pathways for intracellular cholesterol accumulation: common pathogenic mechanisms in Niemann-Pick disease Type C and cystic fibrosisStructure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of CholesterolA PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivoThe promise and perils of HDAC inhibitors in neurodegenerationBinding domain-driven intracellular trafficking of sterols for synthesis of steroid hormones, bile acids and oxysterolsMLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 proteinLoss of Niemann-Pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathwayProtein replacement therapy partially corrects the cholesterol-storage phenotype in a mouse model of Niemann-Pick type C2 diseaseGene Atlasing of digestive and reproductive tissues in Schistosoma mansoniActivation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cellsPathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathwayNiemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 bindingEfficacy and ototoxicity of different cyclodextrins in Niemann-Pick C diseaseCholesterol binding to ion channelsThe Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments.EhNPC1 and EhNPC2 Proteins Participate in Trafficking of Exogenous Cholesterol in Entamoeba histolytica Trophozoites: Relevance for Phagocytosis.Proteins that bind and move lipids: MsbA and NPC1.Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol contentIntracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease.Lysosomal exocytosis and lipid storage disorders.Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo.Adaptations of energy metabolism associated with increased levels of mitochondrial cholesterol in Niemann-Pick type C1-deficient cells.Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.Multi-system disorders of glycosphingolipid and ganglioside metabolismCellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.Cholesterol, the central lipid of mammalian cellsTranscriptome of American oysters, Crassostrea virginica, in response to bacterial challenge: insights into potential mechanisms of disease resistanceGenetic connections between neurological disorders and cholesterol metabolismTherapeutic potential of cyclodextrins in the treatment of Niemann-Pick type C disease.A marked paucity of granule cells in the developing cerebellum of the Npc1(-/-) mouse is corrected by a single injection of hydroxypropyl-β-cyclodextrin
P2860
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P2860
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@ast
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@en
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@en-gb
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@nl
type
label
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@ast
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@en
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@en-gb
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@nl
prefLabel
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@ast
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@en
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@en-gb
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@nl
P2093
P2860
P921
P3181
P356
P1476
NPC2 facilitates bidirectional ...... lesterol egress from lysosomes
@en
P2093
Hyock Joo Kwon
Michael L Wang
Michael S Brown
Rodney E Infante
P2860
P304
15287-15292
P3181
P356
10.1073/PNAS.0807328105
P407
P577
2008-09-04T00:00:00Z