Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection - Wikidata - wikimedia - TriplyDB

Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection

Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection

http://www.wikidata.org/entity/Q24311064

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Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins Anthrax lethal and edema toxins in anthrax pathogenesis Bacillus anthracis edema factor substrate specificity: evidence for new modes of action The potential contributions of lethal and edema toxins to the pathogenesis of anthrax associated shock Lethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapy Differential binding of tenofovir and adefovir to reverse transcriptase of hepatitis B virus Noninvasive imaging technologies reveal edema toxin as a key virulence factor in anthrax Molecular motions as a drug target: mechanistic simulations of anthrax toxin edema factor function led to the discovery of novel allosteric inhibitors.Peptide inhibitors MAP the way towards fighting anthrax pathogenesis.Cationic polyamines inhibit anthrax lethal factor protease Novel inhibitors of anthrax edema factor.Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor.Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.New developments in vaccines, inhibitors of anthrax toxins, and antibiotic therapeutics for Bacillus anthracis.Structural basis of anthrax edema factor neutralization by a neutralizing antibody Antiviral treatment of chronic hepatitis B virus (HBV) infections Acyclic nucleoside phosphonates: a key class of antiviral drugs.A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model.B. anthracis associated cardiovascular dysfunction and shock: the potential contribution of both non-toxin and toxin components Designing inhibitors of anthrax toxin Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice Emergence of anthrax edema toxin as a master manipulator of macrophage and B cell functions Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor Inhibitors of membranous adenylyl cyclases.Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin.Antivirals and antiviral strategies.Antitoxins: novel strategies to target agents of bioterrorism.The evolving field of biodefence: therapeutic developments and diagnostics.Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus New insights into the pathogenesis and treatment of anthrax toxin-induced shock.Potential biological targets of Bacillus anthracis in anti-infective approaches against the threat of bioterrorism.B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model 4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity The adenylyl cyclase activity of anthrax edema factor.Fusion protein of Delta 27LFn and EFn has the potential as a novel anthrax toxin inhibitor.An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis.

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P2860

Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection

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Chyung-Ru Wang

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Craig S Gibbs

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P2860

Genome sequence of Yersinia pestis, the causative agent of plague

Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin

Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins

Crystal structure of the anthrax toxin protective antigen

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Identification of the cellular receptor for anthrax toxin

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