Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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Identification of novel functional inhibitors of acid sphingomyelinaseChemoinformatic analysis of GRAS (Generally Recognized as Safe) flavor chemicals and natural productsNew classes of alanine racemase inhibitors identified by high-throughput screening show antimicrobial activity against Mycobacterium tuberculosisEvaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activityTowards Robot Scientists for autonomous scientific discovery.Bioinformatics in crosslinking chemistry of collagen with selective cross linkersGenome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeastDNA display II. Genetic manipulation of combinatorial chemistry libraries for small-molecule evolutionBitterDB: a database of bitter compoundsUsing checklists and algorithms to improve qualitative exposure judgment accuracyA system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixturesHow drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionWhen Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility CrisisInhibition of Chikungunya Virus Replication by 1-[(2-Methylbenzimidazol-1-yl) Methyl]-2-Oxo-Indolin-3-ylidene] Amino] Thiourea(MBZM-N-IBT)Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infectionPotencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malariaNitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophoreSpecific small molecule inhibitors of Skp2-mediated p27 degradationGlioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2Identification of a better Homo sapiens Class II HDAC inhibitor through binding energy calculations and descriptor analysisReceptor heteromerization and drug discovery.The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasisBeyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteinsPhysiology and pharmacology of the vanilloid receptorDe novo discovery of serotonin N-acetyltransferase inhibitorsN-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonistsIdentification of a chemical probe for NAADP by virtual screeningThe Ehrlich pathway for fusel alcohol production: a century of research on Saccharomyces cerevisiae metabolismShape shifting leads to small-molecule allosteric drug discoveryHot spots in prion protein for pathogenic conversionFinding the needle in the haystack: why high-throughput screening is good for your health.Assessment of prediction confidence and domain extrapolation of two structure-activity relationship models for predicting estrogen receptor binding activitySuperLigands - a database of ligand structures derived from the Protein Data BankOridonin, a Promising ent-Kaurane Diterpenoid Lead CompoundProcess of Fragment-Based Lead Discovery-A Perspective from NMRVeterinary Medicine Needs New Green Antimicrobial DrugsDirect Human Contact with Siloxanes (Silicones) - Safety or Risk Part 1. Characteristics of Siloxanes (Silicones)Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current SolutionsNew agents for the treatment of drug-resistant Mycobacterium tuberculosisCritical questions in development of targeted nanoparticle therapeutics
P2860
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P2860
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Experimental and computational ...... overy and development settings
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Experimental and computational ...... overy and development settings
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Experimental and computational ...... overy and development settings
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type
label
Experimental and computational ...... overy and development settings
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Experimental and computational ...... overy and development settings
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Experimental and computational ...... overy and development settings
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prefLabel
Experimental and computational ...... overy and development settings
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Experimental and computational ...... overy and development settings
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Experimental and computational ...... overy and development settings
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P2093
P3181
P1476
Experimental and computational ...... overy and development settings
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P2093
B W Dominy
C A Lipinski
F Lombardo
P J Feeney
P3181
P356
10.1016/S0169-409X(00)00129-0
P407
P577
2001-03-01T00:00:00Z