Identification and purification of human Stat proteins activated in response to interleukin-2
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Requirements for interleukin-4-induced gene expression and functional characterization of Stat6Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cellsHrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growthDifferent interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferationA single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Integrating non-coding RNAs in JAK-STAT regulatory networksSignal transducer and activator of transcription 5A/B in prostate and breast cancersInterleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytesp70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytesStat5b is essential for natural killer cell-mediated proliferation and cytolytic activityDNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sitesDistinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversityTyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity.The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexesMammary gland expression of mouse mammary tumor virus is regulated by a novel element in the long terminal repeat.STAT signaling in the pathogenesis and treatment of cancerDistinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activityStaphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription (Stat proteins)Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2(pan-p)) transform T cells independently of Jak/STAT activation.Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes.Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene inductionThe role of Stat5a and Stat5b in signaling by IL-2 family cytokines.The significance of tetramerization in promoter recruitment by Stat5.Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains.Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activityNitric oxide enhances Th9 cell differentiation and airway inflammation.Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cellsSignaling via the IL-2 and IL-7 receptors from the membrane to the nucleus.Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5.A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5Transcription factor Stat5a/b as a therapeutic target protein for prostate cancer.Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.IL-2 regulates the expression of the tumor suppressor IL-24 in melanoma cells.An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.Coffee polyphenols change the expression of STAT5B and ATF-2 modifying cyclin D1 levels in cancer cellsThe amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals.Interleukin-2 induces beta2-integrin-dependent signal transduction involving the focal adhesion kinase-related protein B (fakB).Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.
P2860
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P2860
Identification and purification of human Stat proteins activated in response to interleukin-2
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Identification and purificatio ...... d in response to interleukin-2
@ast
Identification and purificatio ...... d in response to interleukin-2
@en
Identification and purificatio ...... d in response to interleukin-2
@en-gb
Identification and purificatio ...... d in response to interleukin-2
@nl
type
label
Identification and purificatio ...... d in response to interleukin-2
@ast
Identification and purificatio ...... d in response to interleukin-2
@en
Identification and purificatio ...... d in response to interleukin-2
@en-gb
Identification and purificatio ...... d in response to interleukin-2
@nl
prefLabel
Identification and purificatio ...... d in response to interleukin-2
@ast
Identification and purificatio ...... d in response to interleukin-2
@en
Identification and purificatio ...... d in response to interleukin-2
@en-gb
Identification and purificatio ...... d in response to interleukin-2
@nl
P2093
P921
P1433
P1476
Identification and purificatio ...... d in response to interleukin-2
@en
P2093
P356
10.1016/1074-7613(95)90140-X
P407
P577
1995-04-01T00:00:00Z