The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
about
A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During DiseaseInjured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106BA transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation.TMEM106B expression is reduced in Alzheimer's disease brainsRegulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathologyFrontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiencyThe role of the cytoskeleton and molecular motors in endosomal dynamics.C9ORF72 hexanucleotide repeats in behavioral and motor neuron disease: clinical heterogeneity and pathological diversity.Activity-dependent trafficking of lysosomes in dendrites and dendritic spines.TiME for TMEM106BWhat we know about TMEM106B in neurodegeneration.Mechanisms and functions of lysosome positioning.Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death.BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon.A recurrent de novo mutation in TMEM106B causes hypomyelinating leukodystrophy.Effects of mutating α-tubulin lysine 40 on sensory dendrite development.MAP6 interacts with Tctex1 and Cav 2.2/N-type calcium channels to regulate calcium signalling in neurons.Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomesThe lysosomal function of progranulin, a guardian against neurodegeneration
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The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
description
2014 nî lūn-bûn
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2014 թուականի Մարտին հրատարակուած գիտական յօդուած
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2014 թվականի մարտին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
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name
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@ast
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@en
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@en-gb
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@nl
type
label
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@ast
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@en
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@en-gb
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@nl
prefLabel
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@ast
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@en
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@en-gb
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@nl
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The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
@en
P2093
Benjamin M Schwenk
Casper C Hoogenraad
Christina M Lang
Denise Orozco
Kristin Rentzsch
Sabina Tahirovic
Sebastian Hogl
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P304
P3181
P356
10.1002/EMBJ.201385857
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P577
2014-03-03T00:00:00Z