Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.
about
A recurrent de novo mutation in TMEM106B causes hypomyelinating leukodystrophy.Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point?TMEM106B and myelination: rare leukodystrophy families reveal unexpected connections.Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.The lysosomal function of progranulin, a guardian against neurodegenerationEarly lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
P2860
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P2860
Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.
description
2017 nî lūn-bûn
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2017年の論文
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年學術文章
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2017年學術文章
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2017年學術文章
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name
Loss of TMEM106B Ameliorates L ...... in Progranulin-Deficient Mice.
@en
Loss of TMEM106B Ameliorates L ...... in Progranulin-Deficient Mice.
@nl
type
label
Loss of TMEM106B Ameliorates L ...... in Progranulin-Deficient Mice.
@en
Loss of TMEM106B Ameliorates L ...... in Progranulin-Deficient Mice.
@nl
prefLabel
Loss of TMEM106B Ameliorates L ...... in Progranulin-Deficient Mice.
@en
Loss of TMEM106B Ameliorates L ...... in Progranulin-Deficient Mice.
@nl
P2093
P2860
P50
P1433
P1476
Loss of TMEM106B Ameliorates L ...... in Progranulin-Deficient Mice
@en
P2093
Hideyuki Takahashi
Melissa Zhou
TuKiet T Lam
Zoe A Klein
P2860
P304
281-296.e6
P356
10.1016/J.NEURON.2017.06.026
P407
P577
2017-07-01T00:00:00Z