TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression
about
Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemiaImmature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors.RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangementFLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitorsPrediction of DNA binding motifs from 3D models of transcription factors; identifying TLX3 regulated genes.Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.An Rb1-dependent amplification loop between Ets1 and Zeb1 is evident in thymocyte differentiation and invasive lung adenocarcinomaRegulated Expression of miR-155 is Required for iNKT Cell DevelopmentThe C228T mutation of TERT promoter frequently occurs in bladder cancer stem cells and contributes to tumorigenesis of bladder cancer.Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress.An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts.Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemiaThe complexity of thyroid transcription factor 1 with both pro- and anti-oncogenic activitiesThe prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest.Candidate luminal B breast cancer genes identified by genome, gene expression and DNA methylation profilingThe molecular basis of T cell acute lymphoblastic leukemiaBreakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia.Repressed BMP signaling reactivates NKL homeobox gene MSX1 in a T-ALL subset.Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.Role of Ets Proteins in Development, Differentiation, and Function of T-Cell Subsets.Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia.The genetics and molecular biology of T-ALL.Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development.Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.A TCR-switchable cell death pathway in T-ALL.NKL homeobox gene MSX1 acts like a tumor suppressor in NK-cell leukemia.Novel insights on TLX1 function in T-ALL pave the way towards differentiation therapy.Aberrant expression of aldehyde dehydrogenase 1A (ALDH1A) subfamily genes in acute lymphoblastic leukaemia is a common feature of T-lineage tumours.TCRα rearrangements identify a subgroup of NKL-deregulated adult T-ALLs associated with favorable outcome.MYC fails to efficiently shape malignant transformation in T-cell acute lymphoblastic leukemia.ETS1 and SP1 drive DHX15 expression in acute lymphoblastic leukaemia.Aberrant activity of NKL homeobox gene NKX3-2 in a T-ALL subset.Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic LeukemiaGene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer
P2860
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P2860
TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@ast
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@en
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@en-gb
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@nl
type
label
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@ast
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@en
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@en-gb
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@nl
prefLabel
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@ast
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@en
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@en-gb
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@nl
P2093
P50
P1433
P1476
TLX homeodomain oncogenes medi ...... ession of TCRα gene expression
@en
P2093
Anton W Langerak
Bertrand Nadel
Corinne Millien
Dominique Payet-Bornet
Elizabeth A Macintyre
Elodie Vachez
Els Verhoeyen
Isabelle Radford
Joaquin Zacarias-Cabeza
Julie Bergeron
P304
P356
10.1016/J.CCR.2012.02.013
P407
P50
P577
2012-04-17T00:00:00Z