The molecular basis of T cell acute lymphoblastic leukemia - Wikidata - wikimedia - TriplyDB

The molecular basis of T cell acute lymphoblastic leukemia

The molecular basis of T cell acute lymphoblastic leukemia

http://www.wikidata.org/entity/Q38047834

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Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights Childhood acute lymphoblastic leukemia: Integrating genomics into therapy Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia Increased leukemia-associated gene expression in benzene-exposed workers Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia Effects of valproic acid and pioglitazone on cell cycle progression and proliferation of T-cell acute lymphoblastic leukemia Jurkat cells MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children's Oncology Group Study.Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia.Neutrophil Gelatinase-Associated Lipocalin (NGAL), Pro-Matrix Metalloproteinase-9 (pro-MMP-9) and Their Complex Pro-MMP-9/NGAL in Leukaemias.Wnt5a and CCL25 promote adult T-cell acute lymphoblastic leukemia cell migration, invasion and metastasis.Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia.Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.Low PKCα expression within the MRD-HR stratum defines a new subgroup of childhood T-ALL with very poor outcome.A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression Human HMGA2 protein overexpressed in mice induces precursor T-cell lymphoblastic leukemia Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia Activation of proto-oncogenes by disruption of chromosome neighborhoods.Biology of childhood acute lymphoblastic leukemia.When cancer and immunology meet SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas Site- and allele-specific polycomb dysregulation in T-cell leukaemia Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia Developmental exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin attenuates later-life Notch1-mediated T cell development and leukemogenesis.The Expression and Prognostic Impact of CD95 Death Receptor and CD20, CD34 and CD44 Differentiation Markers in Pediatric Acute Lymphoblastic Leukemia The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia Controlling pre-leukemic thymocyte self-renewal.Mutational spectrum of adult T-ALL Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL Therapeutic targeting of HES1 transcriptional programs in T-ALL Frequency and distribution of Notch mutations in tumor cell lines.Recurrent somatic mutations in regulatory regions of human cancer genomes High rates of submicroscopic aberrations in karyotypically normal acute lymphoblastic leukemia.PHF6 Degrees of Separation: The Multifaceted Roles of a Chromatin Adaptor Protein.Notch signaling in skeletal health and disease.

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The molecular basis of T cell acute lymphoblastic leukemia

http://www.wikidata.org/entity/Q38047834

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The molecular basis of T cell acute lymphoblastic leukemia

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The molecular basis of T cell acute lymphoblastic leukemia

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The molecular basis of T cell acute lymphoblastic leukemia

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Journal of Clinical Investigation

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The molecular basis of T cell acute lymphoblastic leukemia

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Adolfo Ferrando

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P2860

TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)

TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression

TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3

The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13

The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes

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3398-3406

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scholarly article

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10.1172/JCI61269

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10

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122

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Pieter Van Vlierberghe

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2012-10-01T00:00:00Z

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23023710

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3461904

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