Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart
about
Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype.Mechanisms underlying skin disorders induced by EGFR inhibitorsAmphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulationEpidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury.Cross-talk between EGF and BMP9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cellsConditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes.ErbB signaling in cardiac development and disease.The influence of tethered epidermal growth factor on connective tissue progenitor colony formation.Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo.iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signalingThe stimulation of adipose-derived stem cell differentiation and mineralization by ordered rod-like fluorapatite coatings.The EGF receptor is required for efficient liver regenerationPartitioning the heart: mechanisms of cardiac septation and valve developmentIncreased differentiation capacity of bone marrow-derived mesenchymal stem cells in aquaporin-5 deficiency.Ras-related signaling pathways in valve development: ebb and flow.Hereditary gingival fibromatosis: a systematic review.Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology.Valvulogenesis: the moving target.Genetically engineered mouse models for skin research: taking the next stepADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.The role of Neuregulin-1beta/ErbB signaling in the heart.Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytesReduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice.EGFR family: structure physiology signalling and therapeutic targets.Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment.Epidermal growth factor signalling and bone metastasis.What chick and mouse models have taught us about the role of the endocardium in congenital heart disease.The voyage of stem cell toward terminal differentiation: a brief overview.EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers.Chondrocyte hypertrophy in skeletal development, growth, and disease.The critical role of the epidermal growth factor receptor in endochondral ossification.EGF Inhibits Wnt/β-Catenin-Induced Osteoblast Differentiation by Promoting β-Catenin Degradation.miR-96 promotes osteogenic differentiation by suppressing HBEGF-EGFR signaling in osteoblastic cells.EGFR-AKT-mTOR activation mediates epiregulin-induced pleiotropic functions in cultured osteoblasts.ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phosholipase C γ1 and protein kinase C pathways.Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells.Epidermal growth factor receptor signalling contributes to osteoblastic stromal cell proliferation, osteoclastogenesis and disease progression in giant cell tumour of bone.Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.
P2860
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P2860
Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@ast
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@en
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@en-gb
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@nl
type
label
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@ast
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@en
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@en-gb
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@nl
prefLabel
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@ast
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@en
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@en-gb
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@nl
P2093
P356
P1433
P1476
Mice humanised for the EGF rec ...... otypes in skin, bone and heart
@en
P2093
Astrid Hoebertz
Bettina Wagner
Candace Elliott
Silvia Marino
Wolfram Jochum
P304
P356
10.1242/DEV.00664
P407
P577
2003-10-01T00:00:00Z