Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
about
Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humansThe Janus kinases (Jaks)Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxiaIdentification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesisJAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatinJanus kinases in immune cell signalingInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayIdentification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein.The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesisThe Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factorsTpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondiiTherapeutic targeting of Janus kinasesSuppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivoJanus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Integrating Immunologic Signaling Networks: The JAK/STAT Pathway in Colitis and Colitis-Associated CancerRisk of Infectious Complications in Hemato-Oncological Patients Treated with Kinase InhibitorsTargeting JAK2 in the therapy of myeloproliferative neoplasmsInflammatory pathways of importance for management of inflammatory bowel diseaseAdvances in the management of myelofibrosisStructure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibitionCIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptorThe SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotesLnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathwaysA developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domainRole of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cellsEssential role of synoviolin in embryogenesisTyrosine kinase inhibitors for the treatment of rheumatoid arthritisDrosophila unpaired encodes a secreted protein that activates the JAK signaling pathwayCoupling of heterotrimeric Gi proteins to the erythropoietin receptor.A time- and dose-dependent STAT1 expression system.JAK and MPL mutations in myeloid malignancies.Ruxolitinib: a new JAK1/2 inhibitor that offers promising options for treatment of myelofibrosis.Efficacy of ruxolitinib for myelofibrosis.Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis.MS-1020 is a novel small molecule that selectively inhibits JAK3 activity.Specificity of signaling by hematopoietic cytokine receptors: instructive versus permissive effects.
P2860
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P2860
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@ast
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@en
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@en-gb
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@nl
type
label
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@ast
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@en
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@en-gb
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@nl
prefLabel
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@ast
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@en
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@en-gb
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@nl
P2093
P921
P3181
P1433
P1476
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
@en
P2093
P304
P3181
P356
10.1016/S0092-8674(00)81168-X
P407
P577
1998-05-01T00:00:00Z