Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
about
Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of ParkinsonismDifferential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathwaysLRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site statusPhosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsLRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectivesArsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistributionLack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955.LRRK2 and ubiquitination: implications for kinase inhibitor therapyActivation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).Leucine-rich repeat kinase 2 inhibitors: a review of recent patents (2011 - 2013).Cellular processes associated with LRRK2 function and dysfunctionLRRK2 Pathways Leading to Neurodegeneration.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradationLRRK2 dephosphorylation increases its ubiquitination.Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker.Can the increasing number of newly developed leucine-rich repeat kinase 2 inhibitors validate or invalidate a potential disease-modifying therapeutic approach for Parkinson's disease?PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.The LRRK2 signalling system.Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease.Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.Regulation of LRRK2 by Phosphatases.Molecular Insights and Functional Implication of LRRK2 Dimerization.LRRK2 Phosphorylation.
P2860
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P2860
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@ast
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@en
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@en-gb
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@nl
type
label
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@ast
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@en
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@en-gb
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@nl
prefLabel
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@ast
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@en
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@en-gb
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
@en
P2093
Aleksandra Beylina
Evy Lobbestael
Fangye Gao
Iakov N Rudenko
Justin Wetter
R Jeremy Nichols
P2860
P304
P3181
P356
10.1042/BJ20121772
P407
P577
2013-11-15T00:00:00Z