The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction
about
The Janus kinases (Jaks)Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseLimitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursorsVaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activationInvolvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infectionInterleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase familyMolecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytesIdentification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptorThe structure of the gene for the second chain of the human interferon-gamma receptorDifferences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptorJanus kinases in immune cell signalingPhosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 proteinProtein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factorsInterferon-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon-stimulated gene factor threeTyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activationDirect binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinaseJAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal regionTranscriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathwayCutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphataseFunctional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signalingThe amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptorActivation and association of Stat3 with Src in v-Src-transformed cell linesFunctional regions of the mouse interleukin-10 receptor cytoplasmic domainJanus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Profile of tofacitinib citrate and its potential in the treatment of moderate-to-severe chronic plaque psoriasisJakpot! New small molecules in autoimmune and inflammatory diseasesInflammatory pathways of importance for management of inflammatory bowel diseaseMarburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola VirusHigh-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction.The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.STAM2, a new member of the STAM family, binding to the Janus kinasesArginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signalingChoice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptorsThe conserved box 1 motif of cytokine receptors is required for association with JAK kinasesStat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiationThe type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein
P2860
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P2860
The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction
description
1993 nî lūn-bûn
@nan
1993 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The protein tyrosine kinase JA ...... and -gamma signal transduction
@ast
The protein tyrosine kinase JA ...... and -gamma signal transduction
@en
The protein tyrosine kinase JA ...... and -gamma signal transduction
@en-gb
The protein tyrosine kinase JA ...... and -gamma signal transduction
@nl
type
label
The protein tyrosine kinase JA ...... and -gamma signal transduction
@ast
The protein tyrosine kinase JA ...... and -gamma signal transduction
@en
The protein tyrosine kinase JA ...... and -gamma signal transduction
@en-gb
The protein tyrosine kinase JA ...... and -gamma signal transduction
@nl
prefLabel
The protein tyrosine kinase JA ...... and -gamma signal transduction
@ast
The protein tyrosine kinase JA ...... and -gamma signal transduction
@en
The protein tyrosine kinase JA ...... and -gamma signal transduction
@en-gb
The protein tyrosine kinase JA ...... and -gamma signal transduction
@nl
P2093
P921
P3181
P356
P1433
P1476
The protein tyrosine kinase JA ...... and -gamma signal transduction
@en
P2093
A G Harpur
A Ziemiecki
B A Witthuhn
C Schindler
G Barbieri
O Silvennoinen
P2888
P304
P3181
P356
10.1038/366129A0
P407
P577
1993-11-11T00:00:00Z
P5875
P6179
1053037655