The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor - Wikidata - wikimedia - TriplyDB

The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor

The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor

http://www.wikidata.org/entity/Q24649983

about

SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor Principles of interleukin (IL)-6-type cytokine signalling and its regulation Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity Signaling by STATs Ubiquitination-mediated regulation of interferon responses The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part IV)TYK2 kinase activity is required for functional type I interferon responses in vivo Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor Combining multiple structure and sequence alignments to improve sequence detection and alignment: application to the SH2 domains of Janus kinases.A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling.The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha.Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain.IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled.Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels.Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1.Janus kinases: components of multiple signaling pathways.Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited.Multiplex SNP genotyping in pooled DNA samples by a four-colour microarray system.Interferon-stimulated genes: a complex web of host defenses.The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.Jak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies.Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2 Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression.In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies Glucocorticoid modulation of cytokine signaling.The role of Janus kinases in haemopoiesis and haematological malignancy.Hematopoietic cytokine receptor signaling.Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system.Eliminative signaling by Janus kinases: role in the downregulation of associated receptors.Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases Recent advances in understanding viral evasion of type I interferon.

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The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor

http://www.wikidata.org/entity/Q24649983

description

1997 nî lūn-bûn

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1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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1997 թվականի հոտեմբերին հրատարակված գիտական հոդված

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1997年の論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年论文

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name

The amino-terminal region of T ...... interferon alpha/beta receptor

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The amino-terminal region of T ...... interferon alpha/beta receptor

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The amino-terminal region of T ...... interferon alpha/beta receptor

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The amino-terminal region of T ...... interferon alpha/beta receptor

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The amino-terminal region of T ...... interferon alpha/beta receptor

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PNAS.94.22.11839

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Proceedings of the National Academy of Sciences of the United States of America

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The amino-terminal region of T ...... interferon alpha/beta receptor

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P2093

G Barbieri

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G Uzé

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L Ling

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M C Gauzzi

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M F Richter

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P2860

Functional role of type I and type II interferons in antiviral defense

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes

Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

The human interferon alpha/beta receptor: characterization and molecular cloning

Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein

Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling

Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase

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22

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94

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Sandra Pellegrini

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13886672

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9342324

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23625

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