Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes
about
Sodium channel Scn1b null mice exhibit prolonged QT and RR intervalsAnkyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain.Sudden infant death syndrome-associated mutations in the sodium channel beta subunitsVoltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathwayObscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-linePhosphorylation and ankyrin-G binding of the C-terminal domain regulate targeting and function of the ammonium transporter RhBGCell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interactionDual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulationDefects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillationTargeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-BAnkyrin-B regulates Kir6.2 membrane expression and function in heartMolecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndromeViral infection and human disease--insights from minimotifsPhysiological and Pathophysiological Insights of Nav1.4 and Nav1.5 ComparisonChannelopathies from mutations in the cardiac sodium channel protein complexProtein assemblies of sodium and inward rectifier potassium channels control cardiac excitability and arrhythmogenesisXin proteins and intercalated disc maturation, signaling and diseasesCardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic interventionCaMKII-dependent regulation of cardiac Na(+) homeostasisNa+ channel function, regulation, structure, trafficking and sequestrationIon channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac deathSCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmiaThe cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardiumInteractions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated discA mutation in telethonin alters Nav1.5 functionHeterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated diskThe transitional junction: a new functional subcellular domain at the intercalated discCoxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemiaOrdered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytesA β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in miceGenetic engineering of somatic cells to study and improve cardiac functionSudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop.Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane.Distinct functional defect of three novel Brugada syndrome related cardiac sodium channel mutationsExcitability constraints on voltage-gated sodium channelsAnkyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence.Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse modelAssociation of rare missense variants in the second intracellular loop of NaV1.7 sodium channels with familial autism.Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density.Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes.
P2860
043d6738b6947b4221ff4ac639fce06230fe25cb113e09b7c8648bbde078bc3aedf7333279bd3c115e0f49b479d29fd644ac6e97a188b71a0627289f6a9337efb83d4b1a2370c327453d2bce0666726b88458ed6bff6d9f797361ee5143babb642726e52994180407c9f25f7a5e495b95526f4a3b24160a99c223608995a1c7f29a12e5c78af79b83f9cc23ab092032257f34989bc15da6e4a5fa2a80e89afe9e865f13ae6df9c2f4f72297a290e52f3c1e134e2f2bfb048d73298ee620781e05f8829ee7258ece5fa799dc54ade7a2f835219827342763858ede246
P248
Q24294528-EBBEE45F-575E-4BEA-AA3A-AC42E73519DEQ24295272-9E2F8184-D79B-4A2A-B83D-EC90C0DBA952Q24302400-713B7F98-C3D5-40DC-86C6-66AFDA7295F2Q24305894-C0E6B2BC-BC75-4E93-830B-B59493D72CF6Q24311794-399C65B0-A84C-4441-961C-1187900047BAQ24314722-DEAA02C4-D5EB-4718-8FC3-9C0E6C66574EQ24322255-251F9B64-828E-4C85-B469-B89ED901838BQ24322387-00F3E839-5586-491B-977A-C183B3326DFEQ24324744-D09CF3C6-863C-4934-9704-AFB349C2A925Q24337311-550AAFB1-15C7-41AE-99E5-3F4BCD160A30Q24338086-C5E302D7-C58E-4EF6-A78B-B4E9A41063DBQ24634068-0622069F-8491-4E5B-876E-F0CE3D479A4CQ24647289-A3DCCB97-66CF-420D-A781-A2C559634BBEQ26772794-5653EF65-9786-421F-9D59-709D03046526Q26824051-FDF2D3CF-05AC-4F13-B91C-407D2099ED68Q26830051-D370BDBC-4290-4B73-BC90-77FF8CCFBFFAQ26995346-7C613958-A6D3-44BE-AD52-2762C0FF19BDQ26996561-0127A396-870B-4616-8DDB-62C2562CAA31Q26997372-EC1E0822-99E3-4C63-8DD9-082CF7148E29Q27005721-F22E86BA-0C2B-44AE-8945-FC15E6D8A818Q28087459-509BCD01-0389-442D-8E29-EB2B03E1C521Q28116090-408E7D81-0F07-4AB4-9F62-72CFE38FF0BFQ28236977-528A73F9-28DB-4CAB-8637-C9685A749E02Q28238713-9E5B582C-878E-4E34-B2AA-196A7C6886CEQ28276372-3D1C830A-5CC7-4AF4-85B7-9593C85931A5Q28277080-63601715-5277-40C4-A856-E5A9A2C9EAE4Q28297685-079AAA79-E460-4D2A-80D2-9E53266A5862Q28303059-90713A6C-AF56-4726-842E-79297A99D8BAQ28571997-52819642-0728-4527-8162-17B00F76906DQ28587278-54174223-9A34-4CAD-82D9-DF618F7F505BQ30416546-6748440F-64F8-4FAF-B18D-6D7019262734Q30433543-C43CBD0E-2CAB-4284-836B-3878E99C4F30Q30538574-051C3793-FDE5-4C2C-A994-AC8B73F49B31Q33157184-919F55BC-543A-47A4-BF9E-AA5BDEF96627Q33300128-BA325069-7075-4BAE-95EF-A0AB1381D16DQ33302911-EF03CA30-154F-4BA1-80CF-03038E31C1A6Q33533311-AB87B177-E31D-41FB-A544-618514F87E26Q33790438-F930EDC3-2F58-431C-80AA-5F2101B1310DQ33906188-370214B7-4C7E-4652-89AE-A9DC5DFCA44CQ33917022-0B18C026-37F6-4C53-9402-2C1654BF2646
P2860
Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@ast
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@en
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@en-gb
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@nl
type
label
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@ast
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@en
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@en-gb
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@nl
prefLabel
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@ast
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@en
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@en-gb
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@nl
P2093
P2860
P921
P356
P1476
Nav1.5 E1053K mutation causing ...... the surface of cardiomyocytes
@en
P2093
Guy LeMaillet
Ilaria Rivolta
Peter J Mohler
Silvia G Priori
Stephen Lambert
Vann Bennett
P2860
P304
17533-17538
P356
10.1073/PNAS.0403711101
P407
P577
2004-12-03T00:00:00Z