RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
about
Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunctionCarboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosisInsulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeThe atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degenerationCardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivoFunctional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cellsCalpain 10 is required for cell viability and is decreased in the aging kidneyR-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretionApoptotic pathway induced by transduction of RUNX3 in the human gastric carcinoma cell line MKN-1.Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes.A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression.Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide.Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene.Association of diabetes susceptibility gene calpain-10 with pancreatic cancer among smokersInhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic β-cellsEffects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose toleranceGlucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells.Risks and benefits of transplantation in the cure of type 1 diabetes: whole pancreas versus islet transplantation. A single center studyCalpain chronicle--an enzyme family under multidisciplinary characterizationGlucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors.Prime suspect: the TCF7L2 gene and type 2 diabetes risk.p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells.Insulin stimulates primary beta-cell proliferation via Raf-1 kinase.The calpains: modular designs and functional diversity.Calpains and their multiple roles in diabetes mellitus.Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.β Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity.Linking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetesImpact of genetic insights into calpain biology.Nanospaces between endoplasmic reticulum and mitochondria as control centres of pancreatic β-cell metabolism and survival.Role of TRP ion channels in cancer and tumorigenesis.The beneficial effects of taurine to counteract sarcopenia.Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway.Emerging roles of calpain proteolytic systems in macrophage cholesterol handling.Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic β-cells: activation of caspases and ER stress induction.ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells.Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
P2860
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P248
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P2860
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
description
2004 nî lūn-bûn
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2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年學術文章
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name
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@ast
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@en
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@en-gb
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@nl
type
label
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@ast
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@en
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@en-gb
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@nl
prefLabel
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@ast
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@en
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@en-gb
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@nl
P2093
P2860
P921
P356
P1476
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
@en
P2093
Graeme I Bell
Honggang Ye
James D Johnson
Kenichi Otani
Kenneth S Polonsky
Stanley Misler
Yukio Horikawa
Zhiqiang Han
P2860
P304
P356
10.1074/JBC.M401216200
P407
P577
2004-06-04T00:00:00Z